Publications | Kinetic Plate Imager

2021

Authors	Title	Source
Daniela G. Dengler, Qing Sun, John Holleran, Sirkku Pollari, Jannis Beutel, Brock T. Brown, Aki Shinoki Iwaya, Robert Ardecky, Kaleeckal G. Harikumar, Laurence J. Miller, Eduard A. Sergienko	Development of a Testing Funnel for Identification of Small Molecule Modulators Targeting Secretin Receptors	SLAS Discov. 2021 Jan; 26(1): 1-16.
Dominik Loser, Jasmin Schaefer, Timm Danker, Clemens Moller, Markus Brull, Ilinca Suciu, Anna-Katharina Uckert, Stefanie Klima, Marcel Leist, Udo Kraushaar	Human neuronal signaling and communication assays to assess functional neurotoxicity	Arch Toxicol. 2021; 95(1): 229-252.
Tianshu Xiao, Jianming Lu, Jun Zhang, Rebecca I. Johnson, Lindsay G.A. McKay, Nadia Storm, Christy L. Lavine, Hanqin Peng, Yongfei Cai, Sophia Rits-Volloch, Shen Lu, Brian D. Quinlan, Michael Farzan, Michael S. Seaman, Anthony Griffiths, Bing Chen	A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent	Nat Struct Mol Biol. 2021 Feb; 28(2): 202-209.
Jun Li, Jong-Kook Lee, Keiko Miwa, Yuki Kuramoto, Kiyoshi Masuyama, Hideki Yasutake, Satoki Tomoyama, Hiroyuki Nakanishi, Yasushi Sakata	Scaffold-Mediated Developmental Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Are Preserved After External Support Removal	Front Cell Dev Biol. 2021; 9: 591754.
Nicole M. Fisher, Aqeela AlHashim, Aditi B. Buch, Hana Badivuku, Manar M. Samman, Kelly M. Weiss, Gabriela I. Cestero, Mark D. Does, Jerri M. Rook, Craig W. Lindsley, P. Jeffrey Conn, Rocco G. Gogliotti, Colleen M. Niswender	A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes	JCI Insight. 2021 Feb 22; 6(4): e143324.
Kambiz Shekdar, Jessica Langer, Srinivasan Venkatachalan, Lori Schmid, Jonathan Anobile, Purvi Shah, Amy Lancaster, Olga Babich, Olga Dedova, Dennis Sawchuk	Cell engineering method using fluorogenic oligonucleotide signaling probes and flow cytometry	Biotechnol Lett. 2021 Mar 8 : 1-10.
Aurelia C. Balestra, Konstantinos Koussis, Natacha Klages, Steven A. Howell, Helen R. Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J. Perrin, Lorenzo Brusini, Patrizia Arboit, Olalla Sanz, Laura Peces-Barba Castano, Chrislaine Withers-Martinez, Alexandre Hainard, Sonja Ghidelli-Disse, Ambrosius P. Snijders, David A. Baker, Michael J. Blackman, Mathieu Brochet	Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG	Sci Adv. 2021 Mar; 7(13): eabe5396.
Dominik Loser, Maria G. Hinojosa, Jonathan Blum, Jasmin Schaefer, Markus Brull, Ylva Johansson, Ilinca Suciu, Karin Grillberger, Timm Danker, Clemens Moller, Iain Gardner, Gerhard F. Ecker, Susanne H. Bennekou, Anna Forsby, Udo Kraushaar, Marcel Leist	Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons	Arch Toxicol. 2021; 95(6): 2081-2107.
Tomoya Uchimura, Toshifumi Asano, Takao Nakata, Akitsu Hotta, Hidetoshi Sakurai	A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs	Cell Rep Med. 2021 Jun 15; 2(6): 100298.
Polina Isaikina, Ching-Ju Tsai, Nikolaus Dietz, Filip Pamula, Anne Grahl, Kenneth N. Goldie, Ramon Guixa-Gonzalez, Camila Branco, Marianne Paolini-Bertrand, Nicolas Calo, Fabrice Cerini, Gebhard F. X. Schertler, Oliver Hartley, Henning Stahlberg, Timm Maier, Xavier Deupi, Stephan Grzesiek	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist	Sci Adv. 2021 Jun; 7(25): eabg8685.
Masahiko Soga, Takaya Izumi, Isamu Nanchi, Narumi Horita, Miyuki Yamamoto, Shiori Kawasaki, Koichi Ogawa, Masahide Fujita, and Yasuhide Morioka	Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis	Pain Rep. 2021 Sep-Oct; 6(3): e951.
Shiori Kawasaki, Masahiko Soga, Yusuke Sakurai, Isamu Nanchi, Miyuki Yamamoto, Sunao Imai, Tatsuya Takahashi Naoki Tsuno, Toshiyuki Asaki, Yasuhide Morioka, Masahide Fujita	Selective blockade of transient receptor potential vanilloid 4 reduces cyclophosphamide-induced bladder pain in mice	European Journal of Pharmacology Volume 899, 15 May 2021, 174040
Naoki Aizawa, Yoshikazu Fujimori, Osamu Nakanishi, Takemitsu Hayashi, Yoshiaki Goi, Jun-ichi Kobayashi, Tomoe Fujita	Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β3-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity	European Journal of Pharmacology Volume 899, 15 May 2021, 173995
Magdalene M Moran, Bertrand L Chenard, Timothy Strassmaier	Treatment with HC-070, a Potent Inhibitor of TRPC4 and TRPC5, Leads to Anxiolytic and Antidepressant Effects in Mice	Single Cell Biology

2020

Authors	Title	Source
Wayne Childers, Rong Fan, Rogelio Martinez, Dennis J. Colussi, Edward Melenski, Yuxiao Liu, John Gordon, Magid Abou-Gharbia, Marlene A. Jacobson	Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells	Bioorg Med Chem Lett. 2020 Jan 15; 30(2): 126806.
Hiroyuki Ogasawara, Masahiro Furuno, Koji Edamura, Masato Noguchi	Peptides of major basic protein and eosinophil cationic protein activate human mast cells	Biochem Biophys Rep. 2020 Mar; 21: 100719.
Francis Rousset, German Nacher-Soler, Marta Coelho, Sten Ilmjarv, Vivianne Beatrix Christina Kokje, Antoine Marteyn, Yves Cambet, Michael Perny, Marta Roccio, Vincent Jaquet, Pascal Senn, and Karl Heinz Krause	Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss	Redox Biol. 2020 Feb; 30: 101434.
Marta Sanchez-Soto, Ravi Kumar Verma, Blair K.A. Willette, Elizabeth C. Gonye, Annah M. Moore, Amy E. Moritz, Comfort A. Boateng, Hideaki Yano, R. Benjamin Free, Lei Shi, David R. Sibley	A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity	Sci Signal. 2020 Feb 4; 13(617): eaaw5885.
Sayuri Suzuki, Reinhold Penner, Andrea Fleig	TRPM7 contributes to progressive nephropathy	Sci Rep. 2020; 10: 2333.
Giulia Di Marco, Francesca Vallese, Benjamin Jourde, Christian Bergsdorf, Mattia Sturlese, Agnese De Mario, Valerie Techer-Etienne, Dorothea Haasen, Berndt Oberhauser, Simone Schleeger, Giulia Minetti, Stefano Moro, Rosario Rizzuto, Diego De Stefani, Mara Fornaro, Cristina Mammucari	A High-Throughput Screening Identifies MICU1 Targeting Compounds	Cell Rep. 2020 Feb 18; 30(7): 2321-2331.e6.
Tianyu Wang, Shumpei Nakagawa, Takahito Miyake, Genzui Setsu, Sumihiro Kunisue, Kaoru Goto, Akira Hirasawa, Hitoshi Okamura, Yoshiaki Yamaguchi, Masao Doi	Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176	Sci Rep. 2020; 10: 4429.
Martin Kriebel, Julia Ebel, Florian Battke, Stefan Griesbach, and Hansjurgen Volkmer	Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity	Front Mol Neurosci. 2020; 13: 43.
Shunsuke Maehara, Natsuko Yuge, Chika Higashi, Takumi Ota, Junji Furukawa, Takashi Takeuchi	Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM‐878	Neuropsychopharmacol Rep. 2020 Jun; 40(2): 182-189.
Amy E. Moritz, R. Benjamin Free, Warren S. Weiner, Emmanuel O. Akano, Disha Gandhi, Ara Abramyan, Thomas M. Keck, Marc Ferrer, Xin Hu, Noel Southall, Joseph Steiner, Jeffrey Aube, Lei Shi, Kevin J. Frankowski, David R. Sibley	Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist	J Med Chem. 2020 May 28; 63(10): 5526-5567.
Ruslana Bryk, Shashirekha Mundhra, Xiuju Jiang, Madeleine Wood, Daniel Pfau, Elaina Weber, Suna Park, Li Zhang, Colin Wilson, Renier Van der Westhuyzen, Leslie Street, Kelly Chibale, Matthew Zimmerman, Veronique Dartois, Nunzia Pastore, Andrea Ballabio, Natalie Hawryluk, Stacie Canan, Vikram Khetani, Joseph Camardo, Carl Nathan,	Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB	PLoS Pathog. 2020 Jun; 16(6): e1008567.
Yue Fu, David Estoppey, Silvio Roggo, Dominik Pistorius, Florian Fuchs, Christian Studer, Ashraf S. Ibrahim, Thomas Aust, Frederic Grandjean, Manuel Mihalic, Klaus Memmert, Vivian Prindle, Etienne Richard, Ralph Riedl, Sven Schuierer, Eric Weber, Jurg Hunziker, Frank Petersen, Jianshi Tao, Dominic Hoepfner	Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol	Nat Commun. 2020; 11: 3387.
Xiaofei Zhang, Yiding Zhang, Zhen Chen, Tuo Shao, Richard Van, Katsushi Kumata, Xiaoyun Deng, Hualong Fu, Tomoteru Yamasaki, Jian Rong, Kuan Hu, Akiko Hatori, Lin Xie, Qingzhen Yu, Weijian Ye, Hao Xu, Douglas J. Sheffler, Nicholas D. P. Cosford, Yihan Shao, Pingping Tang, Lu Wang, Ming-Rong Zhang, Steven H. Liang	Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2	Theranostics. 2020; 10(24): 11178-11196.
Khairunnisa Mentari Semesta, Ruilin Tian, Martin Kampmann, Mark von Zastrow, Nikoleta G. Tsvetanova	A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling	PLoS Genet. 2020 Oct; 16(10): e1009103.
Xiaowei Hou, Ian R Outhwaite, Leanne Pedi, Stephen Barstow Long	Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation	eLife. 2020; 9: e62772.
Francis Rousset, Vivianne B. C. Kokje, Rebecca Sipione, Dominik Schmidbauer, German Nacher-Soler, Sten Ilmjarv, Marta Coelho, Stefan Fink, Francois Voruz, Antoun El Chemaly, Antoine Marteyn, Hubert Lowenheim, Karl-Heinz Krause, Marcus Muller, Rudolf Gluckert, Pascal Senn	Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons	Front Cell Neurosci. 2020; 14: 395.
Juliette Duchesne De Lamotte, Sylvain Roqueviere, Helene Gautier, Elsa Raban, Celine Boure, Elena Fonfria, Johannes Krupp, Camille Nicoleau	hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins	Front Pharmacol. 2020; 11: 617867.
Stephane Bedut, Ralf Kettenhofen, Jean-Marc D'Angelo	Voltage-sensing optical recording: A method of choice for high-throughput assessment of cardiotropic effects	J Pharmacol Toxicol Methods . 2020 Sep;105:106888.
Takahiro Yamazaki, Chika Takahashi, Yoshimasa Taniguchi, Masataka Narukawa, Takumi Misaka, Yasuhisa Ano	Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells	Biochemical and Biophysical Research Communications Volume 533, Issue 4, 17 December 2020, Pages 704-709
Michael K. Pugsley Bisrat Bekele, Helene Griessel, Tessade Korte, Simon Authier, Anne F.Grobler, Carrie G.Markgraf, Michael J.Curtis	Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery	Journal of Pharmacological and Toxicological Methods Volume 105, September 2020, 106912
David Reiner Aleksandra Zivkovic, Olivier Labeeuw, Stephane Krief, Marc Capet, Holger Stark	Novel pyrrolidinone derivative lacks claimed histamine H3 receptor stimulation in receptor binding and functional studies	European Journal of Medicinal Chemistry Volume 191, 1 April 2020, 112150
Ayako Yoshida, Kouhei Takashima, Tomokazu Shimonaga, Michinori Kadokura, Shotaro Nagase, Shuichi Koda	Establishment of a simple one-step method for oligodendrocyte progenitor cell preparation from rodent brains	Journal of Neuroscience Methods Volume 342, 1 August 2020, 108798
Maxime Jacoupy, Emeline Hamon-Keromen	Monitoring the Mitochondrial Presequence Import Pathway In Living Mammalian Cells with a New Molecular Biosensor	Mitochondrial Medicine pp 441-452
Takasuna, Kiyoshi, Kazusa, Katsuyuki,Hayakawa Tomohiro	Comprehensive Cardiac Safety Assessment using hiPS-cardiomyocytes (Consortium for Safety Assessment using Human iPS Cells: CSAHi)	Current Pharmaceutical Biotechnology, Volume 21, Number 9, 2020, pp. 829-841(13)

2019

Authors	Title	Source
Dennis J. Colussi, Marlene A. Jacobson	Patient-Derived Phenotypic High-Throughput Assay to Identify Small Molecules Restoring Lysosomal Function in Tay-Sachs Disease	SLAS Discov. 2019 Mar;24(3):295-303. doi: 10.1177/2472555218814538. Epub 2019 Jan 7.
Laura B. Duvall, Lavoisier Ramos-Espiritu, Kyrollos E. Barsoum, J. Fraser Glickman, and Leslie B. Vosshall	Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting	CELL Volume 176, ISSUE 4, P687-701.e5, February 07, 2019
Soon-Hee Kim, Misun Seo1, Hongik Hwang1, Dong-Min Moon, Gi Hoon Son, Kyungjin Kim and Hyewhon Rhim	Physical and Functional Interaction between 5-HT₆ Receptor and Nova-1	Exp Neurobiol. 2019 Feb; 28(1): 17-29.
Akiko Koto, Naoto Motoyama, Hiroki Tahara, Sean McGregor, Minoru Moriyama, Takayoshi Okabe, Masayuki Miura, and Laurent Keller	Oxytocin/vasopressin-like peptide inotocin regulates cuticular hydrocarbon synthesis and water balancing in ants	Proc Natl Acad Sci U S A. 2019 Mar 19; 116(12): 5597-5606.
Thomas M Keck, R. Benjamin Free, Marilyn M Day, Sonvia L Brown, Michele S Maddaluna, Griffin Fountain, Charles Cooper, Brooke Fallon, Matthew Holmes, Christopher Stang, Russell Burkhardt, Alessandro Bonifazi, Michael P Ellenberger, Amy Hauck Newman, David R. Sibley, Chun Wu, and Comfort A. Boateng	Dopamine D₄ Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy	J Med Chem. 2019 Apr 11; 62(7): 3722-3740.
Woo Seung Son, Kyu-Sung Jeong, Sang Min Lim, Ae Nim Pae	Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model	Bioorg Med Chem Lett. 2019 May 15;29(10):1168-1172. doi: 10.1016/j.bmcl.2019.03.026. Epub 2019 Mar 21.
Koki Yamamoto, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi	Scaffold hopping of fused piperidine-type NK3 receptor antagonists to reduce environmental impact	Bioorg Med Chem Lett. 2019 May 15;27(10):2019-2026. doi: 10.1016/j.bmcl.2019.03.059. Epub 2019 Apr 1.
Huan Wang, Robert P. Sheehan, Adam C. Palmer, Robert A. Everley, Sarah A. Boswell, Noga Ron-Harel, Alison E. Ringel, Kristina M. Holton, Connor A. Jacobson, Alison R. Erickson, Laura Maliszewski, Marcia C. Haigis, Peter K. Sorger	Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming	Cell Syst. 2019 May 22; 8(5): 412-426.e7.
Haoyu Zeng, Jixin Wang, Holly Clouse, Armando Lagrutta, Frederick Sannajust	Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker	JRSM Cardiovasc Dis. 2019 Jan-Dec; 8: 2048004019854919.
Tevye Jason Stachniak, Emily Lauren Sylwestrak, Peter Scheiffele, Benjamin J. Hall, Anirvan Ghosh	Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons	J Neurosci. 2019 Jun 5; 39(23): 4461-4474.
Zhuo Yang, Yue Wan, Pingdong Tao, Min Qiang, Xue Dong, Chih-Wei Lin, Guang Yang, Tianqing Zheng, Richard A. Lernera	A cell-cell interaction format for selection of high-affinity antibodies to membrane proteins	Proc Natl Acad Sci U S A. 2019 Jul 23; 116(30): 14971-14978.
Rebekka Wegmann, Marilisa Neri, Sven Schuierer, Bilada Bilican, Huyen Hartkopf, Florian Nigsch, Felipa Mapa, Annick Waldt, Rachel Cuttat, Max R. Salick, Joe Raymond, Ajamete Kaykas, Guglielmo Roma, Caroline Gubser Keller	CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data	Genome Biol. 2019; 20: 142.
Matthew J. Birket, Sophie Raibaud, Miriam Lettieri, Antony D. Adamson, Valerie Letang, Pauline Cervello, Nicolas Redon, Gwenaelle Ret, Sandra Viale, Bing Wang, Bruno Biton, Jean-Claude Guillemot, Vincent Mikol, John P. Leonard, Neil A. Hanley, Cecile Orsini, Jean-Michel Itier	A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology	Stem Cell Reports. 2019 Aug 13; 13(2): 380-393.
M. Jacoupy, Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti	The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells	Sci Rep. 2019; 9: 11829.
Chuang-Yu Lin, Michiko Yoshida, Li-Tzu Li, Akihiro Ikenaka, Shiori Oshima, Kazuhiro Nakagawa, Hidetoshi Sakurai, Eriko Matsui, Tatsutoshi Nakahata, Megumu K. Saito	iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases	JCI Insight. 2019 Sep 19; 4(18): e124299.
Aderonke Sofoluwe, Marc Bacchetta, Mehdi Badaoui, Brenda R. Kwak, Marc Chanson	ATP amplifies NADPH-dependent and -independent neutrophil extracellular trap formation	Sci Rep. 2019; 9: 16556.
Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender, Craig William Lindsley	Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators	Lett Drug Des Discov. 2019 Dec; 16(12): 1387-1394.
Eileen Jackson, Marc Heidl, Dominik Imfeld, Laurent Meeus, Rolf Schuetz, Remo Campiche	Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties	Int J Mol Sci. 2019 Dec; 20(24): 6143.
Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, Ivan Kopljar, Karel van Ammel, Fetene Tekle, Ard Teisman, Jin Zhai, Holly Clouse, Jennifer Pierson, Michael Furniss, Armando Lagrutta, Frederick Sannajust, David J Gallacher	Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites	Toxicol Sci 2019 Aug 1;170(2):345-356.
Ivan Kopljar, An N Hermans, Ard Teisman, David J Gallacher, Hua Rong Lu	Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay	J Pharmacol Toxicol Methods . May-Jun 2018;91:80-86.

2018

Authors	Title	Source
Tania Chernov-Rogan, Tianbo Li, Gang Lu, Henry Verschoof, Kuldip Khakh, Steven W. Jones, Maureen H. Beresini, Chang Liu, Daniel F. Ortwine, Steven J. McKerrall, David H. Hackos, Daniel Sutherlin, Charles J. Cohen, and Jun Chen	Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors	PNAS January 23, 2018 115 (4) E792-E801
Philippa Dale, Victoria Head, Mark R.Dowling, Colin W.Taylor	Selective inhibition of histamine-evoked Ca²⁺ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells	Cell Calcium Volume 71, May 2018, Pages 53-64
Malika Faouzi, Ram P. Neupane, Jian Yang, Philip Williams & Reinhold Penner	Areca nut extracts mobilize calcium and release pro-infammatory cytokines from various immune cells	Scientific Reports 8, Article number: 1075 (2018)
Stefan Just, Bertrand L. Chenard, Angelo Ceci, Timothy Strassmaier, Jayhong A. Chong , Nathaniel T. Blair, Randall J. Gallaschun , Donato del Camino, Susan Cantin, Marc D’Amours, Christian Eickmeier, Christopher M. Fanger, Carsten Hecker, David P. Hessler, Bastian Hengerer, Katja S. Kroker, Sam Malekiani, Robert Mihalek, Joseph McLaughlin, Georg Rast, JoAnn Witek, Achim Sauer,Christopher R. Pryce, Magdalene M. Moran	Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice	Published: January 31, 2018 https://doi.org/10.1371/journal.pone.0191225
Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aube J, Frankowski KJ, Sibley DR.	Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D₂ Dopamine Receptor	Front Synaptic Neurosci. 2018; 10: 2.
Kopljar I, Hermans AN, Teisman A, Gallacher DJ, Lu HR.	Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay.	J Pharmacol Toxicol Methods. 2018 May - Jun;91:80-86. doi: 10.1016/j.vascn.2018.02.004. Epub 2018 Feb 6.
Michael C. Burns, Jennifer E. Howes, Qi Sun, Andrew J. Little, DeMarco V. Camper, Jason R. Abbott, Jason Phan, Taekyu Lee, Alex G. Waterson, Olivia W. Rossanese, Stephen W. Fesik	High-throughput screening identifies small molecules that bind to the RAS: SOS: RAS complex and perturb RAS signaling	Anal Biochem. 2018 May 1; 548: 44-52.
Suzuki S, Lis A, Schmitz C, Penner R, Fleig A	The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins	Cell Mol Life Sci. 2018 Aug;75(16):3069-3078. doi: 10.1007/s00018-018-2786-z. Epub 2018 Mar 2.
Stacey P, Wassermann AM, Kammonen L, Impey E, Wilbrey A, Cawkill D	Plate-Based Phenotypic Screening for Pain Using Human iPSC-Derived Sensory Neurons	SLAS Discov. 2018 Jul;23(6):585-596. doi: 10.1177/2472555218764678. Epub 2018 Mar 16.
Aaron M. Bender, Hyekyung P. Cho, Kellie D. Nance, Kaelyn S. Lingenfelter, Vincent B. Luscombe, Patrick R. Gentry, Karl Voigtritter, Alice E. Berizzi, Patrick M. Sexton, Christopher J. Langmead , Arthur Christopoulos, Charles W. Locuson, Thomas M. Bridges, Sichen Chang, Jordan C. O’Neill, Xiaoyan Zhan, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, and Craig W. Lindsley	Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold	ACS Chem Neurosci. 2018 Jul 18;9(7):1572-1581. doi: 10.1021/acschemneuro.8b00126. Epub 2018 Apr 26.
Jerri M. Rook, Jeanette L Bertron, Hyekyung P. Cho, Pedro M Garcia-Barrantes, Sean P Moran, James T Maksymetz, Kellie D Nance, Jonathan W Dickerson, Daniel H Remke, Sichen Chang, Joel Harp, Anna L. Blobaum, Colleen M Niswender, Carrie K. Jones, Shaun R. Stauffer, P. Jeffrey Conn, and Craig W Lindsley	A novel M₁ PAM VU0486846 exerts efficacy in cognition models without displaying agonist activity or cholinergic toxicity	ACS Chem Neurosci. 2018 Sep 19;9(9):2274-2285. doi: 10.1021/acschemneuro.8b00131. Epub 2018 May 8.
Tomoaki M. Kato, Mie Kubota-Sakashita, Noriko Fujimori-Tono, Fumihito Saito, Satoshi Fuke, Akira Masuda, Shigeyoshi Itohara, Hidenori Suzuki, Tadafumi Kato	Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorde	Molecular Psychiatry 23, 2039-2049 (2018)
Yuki Kuramoto, Atsuhiko T.Naito Hiromas Tojo, Taku Sakai, Masamichi Ito, Masato Shibamoto, Akito Nakagawa, Tomoaki Higo, Katsuki Okada, Toshihiro Yamaguchi, Jong-Kook Lee, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata Issei Komuro	Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient	Journal of Molecular and Cellular Cardiology Volume 121, August 2018, Pages 256-265
Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aube J, Lane JR, Frankowski KJ, Sibley DR	Identification of Positive Allosteric Modulators of the D₁ Dopamine Receptor That Act at Diverse Binding Sites	Mol Pharmacol. 2018 Oct; 94(4): 1197-1209.
Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh, Marta Carrara, Indrajit Das, Kim Schneider, Anne Bertolotti	Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B	Cell. 2018 Aug 23; 174(5): 1216-1228.e19.
Roy J.Vaza, Yi Lia, Vinolia Chellaraja, Stephan Reilinga, Theresa Kuntzweilera, Donglai Yang, Hong Shen, Joseph D.Batchelora, Ying Zhang, Xin Chen, Larry R.McLean, Raymond Kosley Jr.	Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators	Bioorg Med Chem Lett. 2018 Oct 15;28(19):3194-3196. doi: 10.1016/j.bmcl.2018.08.022. Epub 2018 Aug 20.
Takahiro Yamazaki, Yumie Morimoto-Kobayashi, Kumiko Koizumi, Chika Takahashi, Shiori Nakajima, Sayoko Kitao, Yoshimasa Taniguchi, Mikio Katayama, Yoshihiro Ogawa	Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue	The Journal of Nutritional Biochemistry Volume 64, February 2019, Pages 80-87
Anton L. Martinez, Jose Brea, Xavier Monroy, Manuel Merlos, Javier Burgueno, Maria Isabel Loza	A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain	SLAS Discov. 2019 Feb;24(2):158-168. doi: 10.1177/2472555218810323. Epub 2018 Nov 1.
Hirotaka Mizuno, Yasuyuki Kihara, Amanda Kussrow, Allison Chen, Manisha Ray, Richard Rivera, Darryl J. Bornhop, and Jerold Chun	Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry	J Lipid Res. 2019 Jan;60(1):212-217. doi: 10.1194/jlr.D089938. Epub 2018 Nov 21.
Ivan Kopljar, Hua Rong Lu, Karel Van Ammel, Martin Otava, Fetene Tekle, Ard Teisman, David J.Gallacher	Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking	Stem Cell Reports. 2018 Dec 11; 11(6): 1365-1377.
Md Munan Shaik, Hanqin Peng, Jianming Lu, Sophia Rits-Volloch, Chen Xu, Maofu Liao & Bing Chen	Structural basis of coreceptor recognition by HIV-1 envelope spike	Nature, volume 565, pages 318-323 (2019)Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D₂ Dopamine Receptor

2017

Authors	Title	Source
Noritaka Furuya, Takaki Momose, Kenji Katsuno, Nobuhiko Fushimi, Hideyuki Muranaka, Chiaki Handa, Tomonaga Ozawa, Takayoshi Kinoshita	The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity	Bioorg Med Chem Lett. 2017 Mar 1;27(5):1233-1236. doi: 10.1016/j.bmcl.2017.01.056. Epub 2017 Jan 21.
Malika Faouzi, Tatiana Kilch, F. David Horgen, Andrea Fleig and Reinhold Penner	The TRPM7 channel kinase regulates store-operated calcium entry	J Physiol. 2017 May 15; 595(10): 3165-3180.
Armando Lagrutta, Christopher P. Regan, Haoyu Zeng, John P. Imredy, Kenneth Koeplinger, Pierre Morissette, Liping Liu, Gordon Wollenberg, Christopher Brynczka, Jose Lebron, Joseph DeGeorge & Frederick Sannajust	Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry	Sci Rep. 2017; 7: 44820.
Caleigh M. Azumaya, Emily L. Days, Paige N. Vinson, Shaun Stauffer,Gary Sulikowski, C. David Weaver, Terunaga Nakagawa	Screening for AMPA receptor auxiliary subunit specific modulators	PLoS One. 2017; 12(3): e0174742.
Heidi (Haibei) Hua, Huayun Denga, Shizhang Linga, Haiyan Suna,Terry Kenakinb, Xinmiao Liangc, Ye Fanga	Chemical genomic analysis of GPR35 signaling	Integr Biol (Camb). 2017 May 22;9(5):451-463. doi: 10.1039/c7ib00005g.
Hiroyuki Tobinaga, Takayuki Kameyama, Miho Oohara, Naotake Kobayashi, Masahide Ohdan, Natsuki Ishizuka, Masaharu Kume, Maki Tomari, Yoshikazu Tanaka, Fumiyo Takahashi, Haruki Kinoshita, Shinji Shimada, Shunji Shinohara, Hiroyuki Kai	Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening	Bioorg Med Chem Lett. 2018 Jul 15;28(13):2338-2342. doi: 10.1016/j.bmcl.2017.04.060. Epub 2017 Apr 19.
Faye Marie Drawnel, Jitao David Zhang, Erich Kung, Natsuyo Aoyama, Fethallah Benmansour, Andrea Araujo Del Rosario, Sannah Jensen Zoffmann, Frederic Delobel, Michael Prummer, Franziska Weibel, Coby Carlson, Blake Anson, Roberto Iacone, Ulrich Certa, Thomas Singer, Martin Ebeling	Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery	Cell Chem Biol. 2017 May 18;24(5):624-634.e3. doi: 10.1016/j.chembiol.2017.03.016. Epub 2017 Apr 20.
Tzu-Ming Wang, Brandon M. Brown, Lunbin Deng, Benjamin D. Sellers, Patrick J. Lupardus, Heidi J.A. Wallweber, Amy Gustafson, Evera Wong, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Jesse E. Hanson	A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain	Neuropharmacology. 2017 Jul 15;121:204-218. doi: 10.1016/j.neuropharm.2017.04.041. Epub 2017 Apr 27.
Chris M. Hempel, Christopher A. Werley, Graham T. Dempsey, David J. Gerber	Targeting neuronal function for CNS drug discovery	Drug Discov Today Technol. 2017 Mar;23:17-25. doi: 10.1016/j.ddtec.2017.03.005. Epub 2017 May 6.
Hiroko Iseoka, Shigeru Miyagawa, MD, PhD, Satsuki Fukushima, MD, PhD, Atsuhiro Saito, PhD, Shigeo Masuda, MD, PhD, Shin Yajima, MD, Emiko Ito, PhD, Nagako Sougawa, PhD, Maki Takeda, PhD, Akima Harada, Jong‐Kook Lee, MD, PhD, Yoshiki Sawa, MD, PhD	Pivotal role of non‐cardiomyocytes in electromechanical and therapeutic potential of induced pluripotent stem cell‐derived engineered cardiac tissue	Tissue Eng Part A. 2018 Feb 1; 24(3-4): 287-300.
Masaaki Ito, Shin-ichiro Egashira, Kazuki Yoshida, Tomoko Mineno, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Michio Ui, Isao Matsuoka	Identification of novel selective P2Y₆ receptor antagonists by high-throughput screening assay	Life Sci. 2017 Jul 1;180:137-142. doi: 10.1016/j.lfs.2017.05.017. Epub 2017 May 17.
Neil J. Daily, Zhong-Wei Du, and Tetsuro Wakatsuki	High-Throughput Phenotyping of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Neurons Using Electric Field Stimulation and High-Speed Fluorescence Imaging	Assay Drug Dev Technol. 2017 Jun 1; 15(4): 178-188.
Xiaofei Zhang, Katsushi Kumata, Tomoteru Yamasaki, Ran Cheng, Akiko Hatori, Longle Ma, Yiding Zhang, Lin Xie, Lu Wang, Hye Jin Kang, Douglas J. Sheffler, Nicholas D. P. Cosford, Ming-Rong Zhang , and Steven H. Liang	Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator [¹¹C]QCA for Imaging of Metabotropic Glutamate Receptor 2	ACS Chem Neurosci. Author manuscript; available in PMC 2017 Dec 20.
Kari Brown, Alyssa Filuta, Marie-Gabrielle Ludwig, Klaus Seuwen, Julian Jaros, Solange Vidal, Kavisha Arora, Anjaparavanda P. Naren, Kathirvel Kandasamy, Kaushik Parthasarathi, Stefan Offermanns, Robert J. Mason, William E. Miller, Jeffrey A. Whitsett, and James P. Bridges	Epithelial Gpr116 regulates pulmonary alveolar homeostasis via G_q/11 signaling	JCI Insight. 2017 Jun 2; 2(11): e93700.
Nobuo Aikawa	The utility of human iPS cell-derived cardiomyocytes in predicting the clinical risk of drugs that display discordance of cardiotoxicity by species	J-stage 2017 Volume 4 Issue 3 Pages 127-136
Ayyadurai S, Gibson AJ, D'Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ	Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.	J Leukoc Biol. 2017 Dec; 102(6): 1299-1312.
Jin RiHong. eYJ Choi, G Keum, G Nam	Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives	Bioorg Med Chem. 2017 Sep 1;25(17):4677-4685. doi: 10.1016/j.bmc.2017.07.008. Epub 2017 Jul 8.
Qiang Ding, Sui Fang, Xueqin Chen, Youxin Wang, Jian Li, Fuyun Tian, Xiang Xu, Bernard Attali, Xin Xie, Zhaobing Gao	TRPA1 channel mediates organophosphate-induced delayed neuropathy	Cell Discovery volume 3, Article number: 17024 (2017)
Naoto Tsuda, Atsuko Kawaji, Toshihiro Sato, Mitsuhiro Takagi, Chika Higashi, Yutak a Kato,Kumiko Ogawa, Hiroyasu Naba, Munetaka Ohkouchi, Masaki Nakamura, Yoshitaka Hosaka &Junichi Sakaki	A novel free fatty acid receptor 1 (GPR40/FFAR1) agonist,MR1704, enhances glucose-dependent insulin secretion andimproves glucose homeostasis in rats	Pharmacol Res Perspect. 2017 Aug; 5(4): e00340.
Kenneth A. Giuliano, Shinichiro Wachi, Lawrence Drew, Danijela Dukovski,Olivia Green, Cecilia Bastos, Matthew D. Cullen, Sheila Hauck, Bradley D. Tait, Benito Munoz, Po-Shun Lee, and John Preston Miller	Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules That Exhibit Functional Synergy with Potentiators and Correctors	SLAS Discov. 2018 Feb; 23(2): 111-121.
Neil J. Daily, Radleigh Santos, Joseph Vecchi, Pinar Kemanli, and Tetsuro Wakatsuki	Calcium Transient Assays for Compound Screening with Human iPSC-derived Cardiomyocytes: Evaluating New Tools	J Evol Stem Cell Res. Author manuscript; available in PMC 2017 Sep 29.
Miss Maki Takeda, Dr. Shigeru Miyagawa, Dr. Satsuki Fukushima, Dr. Atsuhiro Saito, Dr. Emiko Ito, Dr. Akima Harada, Dr. Ryohei Matsuura, Miss Hiroko Iseoka, Dr. Nagako Sougawa, Miss Noriko Mochizuki-Oda, Dr. Michiya Matsusaki, Prof. Mitsuru Akashi, and Prof. Yoshiki Sawa	Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells	Tissue Eng Part C Methods. 2018 Jan 1; 24(1): 56-67.
Litt M J, Cone R D, Ghamari-Langroudi M	Characterization of MC4R Regulation of the Kir7.1 Channel Using the Tl+ Flux Assay.	Methods Mol Biol. 2018;1684:211-222. doi: 10.1007/978-1-4939-7362-0_16.
Naoki Inoue, Taisei Hirouchi, Atsushi Kasai, Shintaro Higashi, Natsumi Hiraki, Shota Tanaka, Takanobu Nakazawa, Kazuto Nunomura, Bangzhong Lin, Akiko Omori, , Atsuko Hayata-Takano, Yoon-Jeong Kim, Takefumi Doi, Akemichi Baba, Hitoshi Hashimoto, Norihito Shintani	Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response	Biochem Biophys Res Commun. 2018 Jan 8;495(2):1992-1997. doi: 10.1016/j.bbrc.2017.11.116. Epub 2017 Nov 24.
Romain Sube, Eric A. Ertel	Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells: An In-Vitro Model to Predict Cardiac Effects of Drugs	JBiSE> Vol.10 No.11, November 2017, DOI: 10.4236/jbise.2017.1011040

2016

Authors	Title	Source
Santulli-Marotto S, Wheeler J, Lacy ER, Boakye K, Luongo J, Wu SJ, Ryan M	CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function	Monoclon Antib Immunodiagn Immunother. 2015 Dec;34(6):373-80. doi: 10.1089/mab.2015.0039.
Stephane Bedut, Christine Seminatore-Nole, Veronique Lamamy, Sarah Caignard, Jean A. Boutin, Olivier Nosjean, Jean-Philippe Stephan, and Francis Coge	High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes	American Journal of Physiology - Heart and Circulatory Physiology Published 1 July 2016 Vol. 311 no. 1, H44-H53 DOI: 10.1152/ajpheart.00793.2015
Haoyu Zeng, Maria I. Roman, Edward Lis, Armando Lagrutta, Frederick Sannajust	Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes	J Pharmacol Toxicol Methods. 2016 May 21. pii: S1056-8719(16)30049-1. doi: 10.1016/j.vascn.2016.05.009.
Kirsten Bayer Andersen, Jens Leander Johansen, Morten Hentzer, Garrick Paul Smith and Gunnar P. H. Dietz	Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP+ and Rotenone Toxicity	Front. Cell. Neurosci. 10:164. doi: 10.3389/fncel.2016.00164
Selvaraj Muthusamy, Soo Min Lee, Minghua Huang, Nam-Chul Cho, Ghilsoo Nam, Ae Nim Pae, Hyewhon Rhim, Gyochang Keum, Kyung Il Choi	Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M₁ Muscarinic Acetylcholine Receptor Agonists	Bulletin of the Korean Chemical Society. Volume 37, Issue 7, pages 1020-1028, Version of Record online: 27 JUN 2016, DOI: 10.1002/bkcs.10811
Olaposi I. Omotuyi, Desmond D. Adebowale, Ayodeji Famuti, Hamada Tsuyoshi	Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain	Bioorganic & Medicinal Chemistry. Available online 4 June 2016, doi:10.1016/j.bmc.2016.06.006
I. O. Omotuyi, Damilare Adebowale, Ayodeji Famuti, Tsuyoshi Hamada	LPA₁ Extracellular Loop residues 115 and 191 are not required for receptor activation but prevent Ki1625 super-antagonism	RSC Adv., 2016, Accepted Manuscript. DOI: 10.1039/C6RA04276G. First published online 20 May 2016
David J. Gallacher, Gary Gintant, Najah Abi‐Gerges, Mark R. Davies, Hua Rong Lu, Kimberley M. Hoagland, Georg Rast, Brian D. Guth, Hugo M. Vargas, Robert L. Hamlin	Cardiac	Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers. Published Online: 24 MAR 2016. DOI: 10.1002/9781119053248.ch9
Jin-feng Yue, Guan-hua Qiao, Ni Liu, Fa-jun Nan, Zhao-bing Gao	Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques	Acta Pharmacol Sin. 2016 Jan;37(1):105-10. doi: 10.1038/aps.2015.142.
Dan Song, Mariko Nishiyama, Sadao Kimura	Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain	J Recept Signal Transduct Res. 2016 Oct;36(5):478-87. doi: 10.3109/10799893.2015.1130056. Epub 2016 Jan 11.
Anja Probst Larsen, Pierre Francotte, Karla Frydenvang, Daniel Tapken, Eric Goffin, Pierre Fraikin, Daniel-Henri Caignard, Pierre Lestage, Laurence Danober, Bernard Pirotte, Jette Sandholm Kastrup	Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure—Activity Relationship at AMPA Receptors	ACS Chem Neurosci. 2016 Mar 16;7(3):378-90. doi: 10.1021/acschemneuro.5b00318. Epub 2016 Feb 1.
Robert A. Volkmann, Christopher M. Fanger, David R. Anderson, Venkata Ramana Sirivolu, Kathy Paschetto, Earl Gordon, Caterina Virginio, Melanie Gleyzes, Bruno Buisson, Esther Steidl, Susanna B. Mierau, Michela Fagiolini, Frank S. Menniti	MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit	PLoS One. 2016 Feb 1;11(2):e0148129. doi: 10.1371/journal.pone.0148129. eCollection 2016.
Hiroshi Iwakura, Katsuko Dote, Mika Bando, Hiroyuki Koyama, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao	Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus	PLoS One. 2016 Feb 5;11(2):e0148639. doi: 10.1371/journal.pone.0148639. eCollection 2016.
Nicholas E. Calcaterra, Daniel J. Hoeppner, Huijun Wei, Andrew E. Jaffe, Brady J. Maher, James C. Barrow	Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening	Sci Rep. 2016 Feb 16;6:19976. doi: 10.1038/srep19976.
Noritoshi Sekido, Jun Kida, Hiroko Mashimo, Daisuke Wakamatsu, Hiroki Okada, Hidekazu Matsuya	Promising Effects of a Novel EP2 and EP3 Receptor Dual Agonist, ONO-8055, on Neurogenic Underactive Bladder in a Rat Lumbar Canal Stenosis Model	J Urol. 2016 Feb 13. pii: S0022-5347(16)00321-9. doi: 10.1016/j.juro.2016.02.064. [Epub ahead of print]
Matthew Volgraf, Benjamin D. Sellers, Yu Jiang, Guosheng Wu, Cuong Q. Ly, Elisia Villemure, Richard M. Pastor, Po-wai Yuen, Aijun Lu, Xifeng Luo, Mingcui Liu, Shun Zhang, Liang Sun, Yuhong Fu, Patrick J. Lupardus, Heidi J.A. Wallweber, Bianca M. Liederer, Gauri Deshmukh, Emile Plise, Suzanne Tay, Paul Reynen, James Herrington, Amy Gustafson, Yichin Liu, Akim Dirksen, Matthias G. A. Dietz, Yanzhou Liu, Tzu-Ming Wang, Jesse E. Hanson, David Hackos, Kimberly Scearce-Levie, Jacob B. Schwarz	Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design	J Med Chem. 2016 Mar 24;59(6):2760-79. doi: 10.1021/acs.jmedchem.5b02010. Epub 2016 Mar 8.
Juan C. del Alamo, Derek Lemons, Ricardo Serrano, Alex Savchenko, Fabio Cerignoli, Rolf Bodmer, Mark Mercola	High throughput physiological screening of iPSC-derived cardiomyocytes for drug development	Biochim Biophys Acta. 2016 Mar 4. pii: S0167-4889(16)30047-7. doi: 10.1016/j.bbamcr.2016.03.003. [Epub ahead of print]
Qing Zhang, Hui Yang, Jing Li, Xin Xie	Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein—Coupled Receptor 84	J Pharmacol Exp Ther. 2016 May;357(2):337-44. doi: 10.1124/jpet.116.232033. Epub 2016 Mar 9.
Koteswara Rao Valasani, Qinru Sun, Du Fang, Zhihua Zhang, Qing Yu, Yaopeng Guo, Jianping Li, Anuradha Roy, Shirley ShiDu Yan	Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction	ACS Med Chem Lett. 2016 Jan 6;7(3):294-9. doi: 10.1021/acsmedchemlett.5b00451. eCollection 2016.
Masaomi Terajima, Yoko Kaneko-Kobayashi, Naoto Nakamura, Masatoshi Yuri, Masashi Hiramoto, Masanori Naitou, Kazuyuki Hattori, Hiroyuki Yokota, Hidekazu Mizuhara, Yasuyuki Higashi	Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor	Eur J Pharmacol. 2016 Jun 5;780:93-105. doi: 10.1016/j.ejphar.2016.03.036. Epub 2016 Mar 19.
Kazumi Koga, Mitsukane Yoshinaga, Yoshikatsu Uematsu, Yuji Nagai, Naoki Miyakoshi, Yoko Shimoda, Masayuki Fujinaga, Takafumi Minamimoto, Ming-Rong Zhang, Makoto Higuchi, Norikazu Ohtake, Tetsuya Suhara, Shigeyuki Chaki	TASP0434299: A Novel Pyridopyrimidin-4-One Derivative as a Radioligand for Vasopressin V1B Receptor	J Pharmacol Exp Ther. 2016 Jun;357(3):495-508. doi: 10.1124/jpet.116.232942. Epub 2016 Mar 30.
Bingqing Xia, Sui Fang, Xueqin Chen, Hong Hu, Peiyuan Chen, Huayi Wang, Zhaobing Gao	MLKL forms cation channels	Cell Res. 2016 May;26(5):517-28. doi: 10.1038/cr.2016.26. Epub 2016 Apr 1.
Arturo Picones, Arlet Loza-Huerta, Pedro Segura-Chama, Cesar O. Lara-Figueroa	Chapter Nine - Contribution of Automated Technologies to Ion Channel Drug Discovery	Adv Protein Chem Struct Biol. 2016;104:357-78. doi: 10.1016/bs.apcsb.2016.01.002. Epub 2016 Mar 3.
Wenkang Huang, Qiancheng Shen, Xubo Su, Mingfei Ji, Xinyi Liu, Yingyi Chen, Shaoyong Lu, Hanyi Zhuang, Jian Zhang	BitterX: a tool for understanding bitter taste in humans	Sci Rep. 2016 Apr 4;6:23450. doi: 10.1038/srep23450.
Zhenwei Su, Emily C. Brown, Weiwei Wang, Roderick MacKinnon	Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels	Proc Natl Acad Sci U S A. 2016 May 17;113(20):5748-53. doi: 10.1073/pnas.1602815113. Epub 2016 Apr 18.
Aleksandra Klimas, Christina M. Ambrosi, Jinzhu Yu, John C. Williams, Harold Bien, Emilia Entcheva	OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology	Nat Commun. 2016 May 10;7:11542. doi: 10.1038/ncomms11542.
Daniel R. Swale, Haruto Kurata, Sujay V. Kharade, Jonathan Sheehan, Rene Raphemot, Karl R. Voigtritter Eric E. Figueroa, Jens Meiler, Anna L. Blobaum, Craig W. Lindsley, Corey R. Hopkins, Jerod S. Denton	ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels	ACS Chem Neurosci. 2016 May 24. [Epub ahead of print]
Takuya Nagashima, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko	Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism	Sci Rep. 2016 May 20;6:26375. doi: 10.1038/srep26375.

2015

Authors	Title	Source
Olaposi I. Omotuyi, Jun Nagai & Hiroshi Ueda	Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA₁ N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation	Scientific Reports 5, Article number: 13343(2015) doi:10.1038/srep13343
Robert L. Bertekap Jr., Neil T. Burford, Zhuyin Li, Andrew Alt	High-Throughput Screening for Allosteric Modulators of GPCRs	G Protein-Coupled Receptors in Drug Discovery. Volume 1335 of the series Methods in Molecular Biology pp 223-240
Minjoo Kim, Youngjae Kim, Seon Hee Seo, Du-Jong Baek, Sun-Joon Min, Gyochang Keum, Hyunah Choo	Synthesis and Biological Evaluation of N³-Alkyl-Thienopyrimidin-4-Ones as mGluR1 Antagonists	Bulletin of the Korean Chemical Society. Volume 36, Issue 5, pages 1439-1451, Version of Record online: 28 APR 2015, DOI: 10.1002/bkcs.10283
Huailing Zhong, Xinyan Huang, Dario Doller	Multiplexing Label-Free and Fluorescence-Based Methods for Pharmacological Characterization of GPCR Ligands	Label-Free Biosensor Methods in Drug Discovery. Part of the series Methods in Pharmacology and Toxicology pp 215-231
Hilde Lavreysen, John Atack	Receptors: Functional Assays	Encyclopedia of Psychopharmacology. pp 1447-1456
Elizabeth A. Ennis, Jane Wright, Cassandra L. Retzlaff, Owen B. McManus, Zhinong Lin, Xiaofang Huang, Meng Wu, Min Li, J. Scott Daniels, Craig W. Lindsley, Corey R. Hopkins, Randy D. Blakely	Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter	ACS Chem Neurosci. 2015 Mar 18;6(3):417-27. doi: 10.1021/cn5001809. Epub 2015 Feb 2.
Masoud Ghamari-Langroudi, Gregory J. Digby, Julien A. Sebag, Glenn L. Millhauser, Rafael Palomino, Robert Matthews, Taneisha Gillyard, Brandon L. Panaro, Iain R. Tough, Helen M. Cox, Jerod S. Denton, Roger D. Cone	G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons	Nature. 2015 Apr 2;520(7545):94-8 doi: 10.1038/nature14051. Epub 2015 Jan 19.
Jennie L. Conroy, R. Benjamin Free, David R. Sibley	Identification of G Protein-Biased Agonists That Fail To Recruit β-Arrestin or Promote Internalization of the D1 Dopamine Receptor	ACS Chem Neurosci. 2015 Apr 15;6(4):681-92. doi: 10.1021/acschemneuro.5b00020. Epub 2015 Feb 20.
Lothar Lindemann, Richard H. Porter, Sebastian H. Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C. Harrison, Axel Paehler, Christoph Funk, Andreas Gloge, Manfred Schneider, Neil J. Parrott, Liudmila Polonchuk, Urs Niederhauser, Stephen R. Morairty, Thomas S. Kilduff, Eric Vieira, Sabine Kolczewski, Juergen Wichmann, Thomas Hartung, Michael Honer, Edilio Borroni, Jean-Luc Moreau, Eric Prinssen, Will Spooren, Joseph G. Wettstein, Georg Jaeschke	Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression	J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C Harrison, Axel Paehler, Christoph Funk, Andreas Gloge, Manfred Schneider, Neil J Parrott, Liudmila Polonchuk, Urs Niederhauser, Stephen R	Pharmacology of basimglurant (RO4917523, RG7090), a unique mGlu5 negative allosteric modulator in clinical development for depression	J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.
Gyeong hi Cho, TaeHun Kim, Woo Seung Son, Seon Hee Seo, Sun-Joon Min, Yong Seo Cho, Gyochang Keum, Kyu-Sung Jeong, Hun Yeong Koh, Jiyoun Lee, Ae Nim Pae	Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: A potential treatment for neuropathic pain	Bioorg Med Chem Lett. 2015 Mar 15;25(6):1324-8. doi: 10.1016/j.bmcl.2015.01.035. Epub 2015 Jan 24.
Ryo Suzuki, Dai Nozawa, Aya Futamura, Rie Nishikawa-Shimono, Masahito Abe, Nobutaka Hattori, Hiroshi Ohta, Yuko Araki, Daiji Kambe, Mari Ohmichi, Seiken Tokura, Takeshi Aoki, Norikazu Ohtake, Hiroshi Kawamoto	Discovery and in vitro and in vivo profiles of N-ethyl-N-[2-[3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl]ethyl]-2-(2H-1,2,3-triazol-2-yl)-benzamide as a novel class of dual orexin receptor antagonist	Bioorg Med Chem. 2015 Mar 15;23(6):1260-75. doi: 10.1016/j.bmc.2015.01.044. Epub 2015 Feb 10.
Yasuo Yonetomi, Tomohiko Sekioka, Michiaki Kadode, Tetsuya Kitamine, Akihiro Kamiya, Naoya Matsumura, Manabu Fujita, Kazuhito Kawabata	Leukotriene C₄ induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs	Eur J Pharmacol. 2015 May 5;754:98-104. doi: 10.1016/j.ejphar.2015.02.014. Epub 2015 Feb 20.
Hamid R. Hoveyda, Graeme L. Fraser, Marie-Odile Roy, Guillaume Dutheuil, Frederic Batt, Mohamed El Bousmaqui, Julien Korac, Francois Lenoir, Alexey Lapin, Sophie Noel, Sebastien Blanc	Discovery and Optimization of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part I)	J Med Chem. 2015 Apr 9;58(7):3060-82. doi: 10.1021/jm5017413. Epub 2015 Mar 18.
Haibo Yu, Beiyan Zou, Xiaoliang Wang, Min Li	Effect of tyrphostin AG879 on Kv4.2 and Kv4.3 potassium channels	Br J Pharmacol. 2015 Jul;172(13):3370-82. doi: 10.1111/bph.13127. Epub 2015 Apr 24.
Ni Ai, Richard D. Wood, William J. Welsh	Identification of Nitazoxanide as a Group I Metabotropic Glutamate Receptor Negative Modulator for the Treatment of Neuropathic Pain: An In Silico Drug Repositioning Study	Pharm Res. 2015 Aug;32(8):2798-807. doi: 10.1007/s11095-015-1665-7. Epub 2015 Mar 12.
Minghua Huang, Dae-Hwan Suk, Nam-Chul Cho, Deepak Bhattarai, Soon Bang Kang, Youseung Kim, Ae Nim Pae, Hyewhon Rhim, Gyochang Keum	Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists	Bioorg Med Chem Lett. 2015 Apr 1;25(7):1546-51. doi: 10.1016/j.bmcl.2015.02.012. Epub 2015 Feb 16.
Shinsaku Yamane, Tomohiro Karakawa, Satoshi Nakayama, Kazufumi Nagai, Kazumi Moriyuki, Shinichi Neki, Fumitaka Suto, Tohru Kambe, Yasushi Hirota, Kazuhito Kawabata	IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys	Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2547-52. doi: 10.1167/iovs.14-16181.
Satoshi Itadani, Shinya Takahashi, Masaki Ima, Tetsuya Sekiguchi, Yoshiyuki Aratani, Hiromu Egashir, Naoya Matsumura, Atsuto Inoue, Yasuo Yonetomi, Manabu Fujita, Yoshisuke Nakayama, Jun Takeuchi	Discovery of a potent, orally available dual CysLT₁ and CysLT₂ antagonist with dicarboxylic acid	Bioorg Med Chem. 2015 May 1;23(9):2079-97. doi: 10.1016/j.bmc.2015.03.011. Epub 2015 Mar 7.
Youngjae Kim, Minjoo Kim, Mooseong Park, Jinsung Tae, Du-Jong Baek, Ki Duk Park, Hyunah Choo	Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives	Molecules. 2015 Mar 19;20(3):5074-84. doi: 10.3390/molecules20035074.
Taro Kato, Makoto Takata, Maiko Kitaichi, Momoe Kassai, Mitsuhiro Inoue, Chihiro Ishikawa, Wataru Hirose, Kozo Yoshida, Isao Shimizu	DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity	Eur J Pharmacol. 2015 Jun 15;757:11-20. doi: 10.1016/j.ejphar.2015.03.024. Epub 2015 Mar 28.
William H. Parsons, Raul R. Calvo, Wing Cheung, Yu-Kai Lee, Sharmila Patel, Jian Liu, Mark A. Youngman, Scott L. Dax, Dennis Stone, Ning Qin, Tasha Hutchinson, Mary Lou Lubin, Sui-Po Zhang, Michael Finley, Yi Liu, Michael R. Brandt, Christopher M. Flores, Mark R. Player	Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)	J Med Chem. 2015 May 14;58(9):3859-74. doi: 10.1021/acs.jmedchem.5b00132. Epub 2015 Apr 15.
Yu Du, Emily Days, Ian Romaine, Kris K. Abney, Kristian Kaufmann, Gary Sulikowski, Shaun Stauffer, Craig W. Lindsley, C. David Weaver	Development and Validation of a Thallium Flux-Based Functional Assay for the Sodium Channel NaV1.7 and Its Utility for Lead Discovery and Compound Profiling	ACS Chem Neurosci. 2015 Jun 17;6(6):871-8. doi: 10.1021/acschemneuro.5b00004. Epub 2015 Apr 30.
Andrew V. Dix, Jennie L. Conroy, Kara M. George Rosenker, David R. Sibley, Daniel H. Appella	PNA-Based Multivalent Scaffolds Activate the Dopamine D₂ Receptor	ACS Med Chem Lett. 2015 Mar 13;6(4):425-9. doi: 10.1021/ml500478m. eCollection 2015.
S.-H. Choi, M.-K. Hong, H.-J. Kim, N. Ryoo, H. Rhim, S.-Y. Nah, L.-W. Kang	Structure of ginseng major latex-like protein 151 and its proposed lysophosphatidic acid-binding mechanism	Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1039-50. doi: 10.1107/S139900471500259X. Epub 2015 Apr 24.
Yu Yoshida, Yoshimitsu Naoe, Taro Terauchi, Fumihiro Ozaki, Takashi Doko, Ayumi Takemura, Toshiaki Tanaka, Keiichi Sorimachi, Carsten T. Beuckmann, Michiyuki Suzuki, Takashi Ueno, Shunsuke Ozaki, Masahiro Yonaga	Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist	J Med Chem. 2015 Jun 11;58(11):4648-64. doi: 10.1021/acs.jmedchem.5b00217. Epub 2015 May 22.
Mina Nam, TaeHun Kim, Jinsook Kwak, d, Seon Hee Seo, Min Kyung Ko, Eun Jeong Lim, Sun-Joon Min, Yong Seo Cho, Gyochang Keum, Du-Jong Baek, Jiyoun Lee, Ae Nim Pae	Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain	Eur J Med Chem. 2015 Jun 5;97:245-58. doi: 10.1016/j.ejmech.2015.04.060. Epub 2015 Apr 30.
Shigeyuki Chaki, Toshiharu Shimazaki, Mariko Nishiguchi, Takeo Funakoshi, Michihiko Iijima, Akie Ito, Kosuke Kanuma, Yoshinori Sekiguchi	Antidepressant/anxiolytic potential and adverse effect liabilities of melanin-concentrating hormone receptor 1 antagonists in animal models	Pharmacol Biochem Behav. 2015 Aug;135:154-68. doi: 10.1016/j.pbb.2015.05.018. Epub 2015 Jun 2.
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Emily Thomas, Sarita Yeola, Jianmin Lao, Mark McPate, J. Martin Verkuyl, George Marsh, Jason Sarber, Adam Amaral, Scott Bailey, Danuta Lubicka, Helen Pham, Nicolette Miranda, Jian Ding, Hai-Ming Tang, Haisong Ju, Pamela Tranter, Nan Ji, Philipp Krastel, Rishi K. Jain, Andrew M. Schumacher, Joseph J. Loureiro, Elizabeth George, Giuliano Berellini, Nathan T. Ross, Simon M. Bushell, Gul Erdemli, Jonathan M. Solomon	Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation	PLoS One. 2015 Jun 22;10(6):e0127498. doi: 10.1371/journal.pone.0127498. eCollection 2015.
Yasuhiro Wada, Hiromitsu Shirahashi, Taisuke Iwanami, Masami Ogawa, Seiji Nakano, Akifumi Morimoto, Ken-ichi Kasahara, Eiichi Tanaka, Yoshio Takada, Shigeki Ohashi, Mutsuhiro Mori, Satoshi Shuto	Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β₃-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects	J Med Chem. 2015 Aug 13;58(15):6048-57. doi: 10.1021/acs.jmedchem.5b00638. Epub 2015 Jul 15.
Icilio Cavero, Henry Holzgrefe	CiPA: Ongoing testing, future qualification procedures, and pending issues	J Pharmacol Toxicol Methods. 2015 Nov-Dec;76:27-37. doi: 10.1016/j.vascn.2015.06.004. Epub 2015 Jul 6.
Satoshi Itadani, Kentaro Yashiro, Yoshiyuki Aratani, Tetsuya Sekiguchi, Atsushi Kinoshita, Hideki Moriguchi, Nobukazu Ohta, Shinya Takahashi, Akiharu Ishida, Yohei Tajima, Katsuya Hisaichi, Masaki Ima, Junya Ueda, Hiromu Egashira, Tomohiko Sekioka, Michiaki Kadode, Yasuo Yonetomi, Takafumi Nakao, Atsuto Inoue, Hiroaki Nomura, Tetsuya Kitamine, Manabu Fujita, Takeshi Nabe, Yoshiyuki Yamaura, Naoya Matsumura, Akira Imagawa, Yoshisuke Nakayama, Jun Takeuchi, Kazuyuki Ohmoto	Discovery of Gemilukast (ONO-6950), a Dual CysLT₁ and CysLT₂ Antagonist As a Therapeutic Agent for Asthma	J Med Chem. 2015 Aug 13;58(15):6093-113. doi: 10.1021/acs.jmedchem.5b00741. Epub 2015 Jul 22.
Cheryl de Valliere, Solange Vidal, Ieuan Clay, Giorgia Jurisic, Irina Tcymbarevich, Silvia Lang, Marie-Gabrielle Ludwig, Michal Okoniewski, Jyrki J. Eloranta, Gerd A. Kullak-Ublick, Carsten A. Wagner, Gerhard Rogler, Klaus Seuwen	The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment	Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G475-90. doi: 10.1152/ajpgi.00408.2014. Epub 2015 Jul 23.
Robert L. BertekapJr.; Neil T. Burford; Zhuyin Li; Andrew Alt	High-Throughput Screening for Allosteric Modulators of GPCRs	Methods Mol Biol. 2015;1335:223-40. doi: 10.1007/978-1-4939-2914-6_15.
Emi Shoji, Hidetoshi Sakurai, Tokiko Nishino, Tatsutoshi Nakahata, Toshio Heike, Tomonari Awaya, Nobuharu Fujii, Yasuko Manabe, Masafumi Matsuo, Atsuko Sehara-Fujisawa	Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells	Sci Rep. 2015 Aug 20;5:12831. doi: 10.1038/srep12831.
Yasuo Yonetomi, Tomohiko Sekioka, Michiaki Kadode, Tetsuya Kitamine, Akihiro Kamiya, Atsuto inoue, Takafumi Nakao, Hiroaki Nomura, Masayuki Murata, Shintaro Nakao, Fumio Nambu, Manabu Fujita, Shinji Nakade, Kazuhito Kawabata	Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma	Eur J Pharmacol. 2015 Oct 15;765:242-8. doi: 10.1016/j.ejphar.2015.08.041. Epub 2015 Aug 28.
Atsushi Nakane, Yusuke Gotoh, Junji Ichihara, Hidetaka Nagata	New screening strategy and analysis for identification of allosteric modulators for glucagon-like peptide-1 receptor using GLP-1 (9-36) amide	Anal. Biochem. 2015 Dec 15;491:23-30. doi: 10.1016/j.ab.2015.08.026. Epub 2015 Sep 2.
Jae Wan Jang, Nam-Chul Cho, Sun-Joon Min, Yong Seo Cho, Ki Duk Park, Seon Hee Seo, Kyoung Tai No, Ae Nim Pae	Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach	Chem Biol Drug Des. 2016 Feb;87(2):239-56. doi: 10.1111/cbdd.12654. Epub 2015 Oct 9.
Yoshiharu Uruno, Yasuko Konishi, Atsushi Suwa, Kentaro Takai, Kengo Tojo, Tomokazu Nakako, Mutsuko Sakai, Takeshi Enomoto, Harumi Matsuda, Atsushi Kitamura, Takaaki Sumiyoshi	Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M₁ and M₄ muscarinic acetylcholine receptors agonists	Bioorg Med Chem Lett. 2015 Nov 15;25(22):5357-61. doi: 10.1016/j.bmcl.2015.09.032. Epub 2015 Sep 12.
Tomohiko Sekioka, Michiaki Kadode, Masanori Fujii, Kazuhito Kawabata, Takashi Abe, Michiaki Horiba, Shigekatsu Kohno, Takeshi Nabe	Expression of CysLT₂ receptors in asthma lung, and their possible role in bronchoconstriction	Allergol Int. 2015 Oct;64(4):351-8. doi: 10.1016/j.alit.2015.04.008. Epub 2015 Jun 3.
Brian Tomkowicz, Eileen Walsh, Adam Cotty, Raluca Verona, Nina Sabins, Fred Kaplan, Sandy Santulli-Marotto, Chen-Ni Chin, Jill Mooney, Russell B. Lingham, Michael Naso, Timothy McCabe	TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway	PLoS One. 2015 Oct 22;10(10):e0140694. doi: 10.1371/journal.pone.0140694. eCollection 2015.
Hilary Highfield Nickols, Joannes P. Yuh, Karen J. Gregory, Ryan D. Morrison, Brittney S. Bates, Shaun R. Stauffer, Kyle A. Emmitte, Michael Bubser, Weimin Peng, Michael T. Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J. Scott Daniels, Colleen M. Niswender, Craig W. Lindsley, Carrie K. Jones,P. Jeffrey Conn	VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy	J Pharmacol Exp Ther. 2016 Jan;356(1):123-36. doi: 10.1124/jpet.115.226597. Epub 2015 Oct 26.
Jesse A. May, Najam A. Sharif, Marsha A. McLaughlin, Hwang-Hsing Chen, Bryon S. Severns, Curtis R. Kelly, William F. Holt, Richard Young, Richard A. Glennon, Mark R. Hellberg, Thomas R. Dean	Ocular Hypotensive Response in Nonhuman Primates of (8R)-1-[(2S)-2-Aminopropyl]-8,9-dihydro-7H-pyrano[2,3-g]indazol-8-ol a Selective 5-HT₂Receptor Agonist	J Med Chem. 2015 Nov 25;58(22):8818-33. doi: 10.1021/acs.jmedchem.5b00857. Epub 2015 Nov 9.
Hoang Nam Vu, Ji Young Kim, Ahmed H.E. Hassan, Kihang Choi Jong-Hyun Park, Ki Duk Park, Jae Kyun Lee, Ae Nim Pae, Hyunah Choo, Sun-Joon Min, Yong Seo Cho	Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists	Bioorg Med Chem Lett. 2016 Jan 1;26(1):140-4. doi: 10.1016/j.bmcl.2015.11.012. Epub 2015 Nov 5.
Jennifer L. Herington, Daniel R. Swale, Naoko Brown, Elaine L. Shelton, Hyehun Choi, Charles H. Williams, Charles C. Hong, Bibhash C. Paria, Jerod S. Denton, Jeff Reese	High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility	PLoS One. 2015 Nov 24;10(11):e0143243. doi: 10.1371/journal.pone.0143243. eCollection 2015.
Hai-bo Yu, Min Li, Wei-ping Wang, Xiao-liang Wang	High throughput screening technologies for ion channels	Acta Pharmacol Sin. 2016 Jan;37(1):34-43. doi: 10.1038/aps.2015.108. Epub 2015 Dec 14.
Abdallah Ahnaou, Hilde Lavreysen, Gary Tresadern, Jose M. Cid, Wilhelmus H. Drinkenburg	mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats	PLoS One. 2015 Dec 11;10(12):e0144017. doi: 10.1371/journal.pone.0144017. eCollection 2015.
Hiroyuki Koyama, Hiroshi Iwakura, Katsuko Dote, Mika Bando, Hiroshi Hosoda, Hiroyuki Ariyasu, Toru Kusakabe, Choel Son, Kiminori Hosoda, Takashi Akamizu, Kenji Kangawa, Kazuwa Nakao	Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells	Endocrinology. 2016 Feb;157(2):692-704. doi: 10.1210/en.2015-1784. Epub 2015 Dec 15.
Sandra Santulli-Marotto, John Wheeler, Eilyn R. Lacy, Ken Boakye, Jennifer Luongo, Sheng-Jiun Wu, Mary Ryan	CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function	Monoclon Antib Immunodiagn Immunother. 2015 Dec;34(6):373-80. doi: 10.1089/mab.2015.0039.
John Broad, Nobuyuki Takahashi, Masaomi Tajimi, Masaki Sudo, Adam Goralczyk, Umesh Parampalli, Kesava Mannur, Toshinori Yamamoto, Gareth J. Sanger	RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions	J Pharmacol Sci. 2016 Feb;130(2):60-5. doi: 10.1016/j.jphs.2015.11.004. Epub 2015 Nov 19.
Haitao Ji, Jong-Ho Lee, Yugang Wang, Yilin Pang, Tao Zhang, Yan Xia, Lianjin Zhong, Jianxin Lyu, Zhimin Lu	EGFR phosphorylates FAM129B to promote Ras activation	Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):644-9. doi: 10.1073/pnas.1517112113. Epub 2015 Dec 31.

2014

Authors	Title	Source
Anke Bill, Elizabeth M. Rosethorne, Toby C. Kent, Lindsay Fawcett, Lynn Burchell, Michiel T. van Diepen, Anthony Marelli, Sergey Batalov, Loren Miraglia, Anthony P. Orth, Nicole A. Renaud, Steven J. Charlton, Martin Gosling, L. Alex Gaither, Paul J. Groot-Kormelink	High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function	PLoS One. 2014 Jun 2;9(6):e97973. doi: 10.1371/journal.pone.0097973. eCollection 2014.
Anke Bill, M. Oana Popa, Michiel T. van Diepen, Abraham Gutierrez, Sarah Lilley, Maria Velkova, Kathryn Acheson, Hedaythul Choudhury, Nicole A. Renaud, Douglas S. Auld, Martin Gosling, Paul J. Groot-Kormelink, L. Alex Gaither	Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation	J Biol Chem. 2015 Jan 9;290(2):889-903. doi: 10.1074/jbc.M114.618140. Epub 2014 Nov 25.
Ann-Beth Norholm, Pierre Francotte, Eric Goffin, Iuliana Botez, Laurence Danober, Pierre Lestage, Bernard Pirotte, Jette S. Kastrup, Lars Olsen, Chris Oostenbrink	Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces	J Chem Inf Model. 2014 Dec 22;54(12):3404-16. doi: 10.1021/ci500559b. Epub 2014 Dec 9.
Anuradha Roy	High Throughput Screening Operations at the University of Kansas	Comb Chem High Throughput Screen. 2014 May;17(4):387-93.
Bin Cai, Xia Chen, Fang Liu, Jun Li, Lijuan Gu, Jason R. Liu, Jay Liu	A Cell-Based Functional Assay Using a Green Fluorescent Protein-Based Calcium Indicator dCys-GCaMP	Assay Drug Dev Technol. 2014 Aug;12(6):342-51. doi: 10.1089/adt.2014.584. Epub 2014 Aug 8.
Cheryse A. Furman, Rebecca A. Roof, Amy E. Moritz, Brittney N. Miller, Trevor B. Doyle, R. Benjamin Free, Ashwini K. Banala, Noel M. Paul, Vivek Kumar, Christopher D. Sibley, Amy Hauck Newman, David R. Sibley	Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists	Eur Neuropsychopharmacol. 2014 Nov 29. pii: S0924-977X(14)00324-1. doi: 10.1016/j.euroneuro.2014.11.013. [Epub ahead of print]
Eunan Hendron, Xizhuo Wang, Yandong Zhou, Xiangyu Cai, Jun-Ichi Goto, Katsuhiko Mikoshiba, Yoshihiro Baba, Tomohiro Kurosaki, Youjun Wang, Donald L. Gill	Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs	Cell Calcium. 2014 Oct 23;56(6):482-492. doi: 10.1016/j.ceca.2014.10.005. [Epub ahead of print]
Frederic Bassilana, Adam Carlson, Jennifer A DaSilva, Bianka Grosshans, Solange Vidal, Valerie Beck, Barbara Wilmeringwetter, Luis A Llamas, Todd B Showalter, Pascal Rigollier, Aaron Bourret, Arun Ramamurthy, Xu Wu, Fred Harbinski, Samantha Plonsky, Lac Lee, Heinz Ruffner, Paola Grandi, Markus Schirle, Jeremy Jenkins, Andreas W Sailer, Tewis Bouwmeester, Jeffrey A Porter, Vic Myer, Peter M Finan et al.	Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39	Nat Chem Biol. 2014 May;10(5):343-9. doi: 10.1038/nchembio.1481. Epub 2014 Mar 16.
Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu, and Min Li	Reporting Sodium Channel Activity Using Calcium Flux: Pharmacological Promiscuity of Cardiac Nav1.5	Mol Pharmacol. 2015 Feb;87(2):207-17. doi: 10.1124/mol.114.094789. Epub 2014 Nov 24.
Hyekyung P. Cho, Darren W. Engers, Daryl F. Venable, Colleen M. Niswender, Craig W. Lindsley, P. Jeffrey Conn, Kyle A. Emmitte, Alice L. Rodriguez	A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and Human Receptors	ACS Chem Neurosci. 2014 Jul 16;5(7):597-610. doi: 10.1021/cn5000343. Epub 2014 May 15.
Hyekyung P. Cho, Pedro M. Garcia-Barrantes, John T. Brogan, Corey R. Hopkins, Colleen M. Niswender, Alice L. Rodriguez, Daryl F. Venable, Ryan D. Morrison, Michael Bubser, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley	Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics	ACS Chem Biol. 2014 Oct 17;9(10):2334-46. doi: 10.1021/cb500560h. Epub 2014 Aug 28.
J. Kyle Bruner, Beiyan Zou, Hongkang Zhang, Yixin Zhang, Katharina Schmidt, Min Li	Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel	Eur J Pharmacol. 2014 Oct 5;740:603-10. doi: 10.1016/j.ejphar.2014.06.021. Epub 2014 Jun 24.
Jesse E. Hanson, William J. Meilandt, Alvin Gogineni, Paul Reynen, James Herrington, Robby M. Weimer, Kimberly Scearce-Levie, Qiang Zhou	Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse Models	J Neurosci. 2014 Jun 11;34(24):8277-88. doi: 10.1523/JNEUROSCI.5106-13.2014.
John W. Kehoe, Brian Whitaker, Deidra Bethea, Eilyn R. Lacy, Ken Boakye, Sandra Santulli-Marotto, Mary H. Ryan, Yiqing Feng, John C. WheelerJohn W. Kehoe, Brian Whitaker, Deidra Bethea, Eilyn R. Lacy, Ken Boakye, Sandra Santulli-Marotto, Mary H. Ryan, Yiqing Feng, John C. Wheeler	Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene	Protein Eng Des Sel. 2014 Jun;27(6):199-206. doi: 10.1093/protein/gzu012. Epub 2014 Apr 16.
Julie A. Meade, R. Benjamin Free, Nicole R. Miller, Lani S. Chun, Trevor B. Doyle, Amy E. Moritz, Jennie L. Conroy, Val J. Watts, David R. Sibley	(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling	Psychopharmacology (Berl). 2014 Sep 18. [Epub ahead of print]
Junki Miyamoto, Taichi Mizukure, Si-Bum Park, Shigenobu Kishino, Ikuo Kimura, Kanako Hirano, Paolo Bergamo, Mauro Rossi, Takuya Suzuki, Makoto Arita, Jun Ogawa, Soichi Tanabe	A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40/MEK-ERK pathway	J Biol Chem. 2014 Dec 10. pii: jbc.M114.610733. [Epub ahead of print]
Kazuyuki Fukushima, Yoshikuni Tabata, Yoichi Imaizumi, Naohiro Kohmura, Michiko Sugawara, Kohei Sawada, Kazuto Yamazaki, Masashi Ito	Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors	J Biomol Screen. 2014 Jun 30;19(8):1174-1184. [Epub ahead of print]
Laykea Tafesse, Toshiyuki Kanemasa, Noriyuki Kurose, Jianming Yu, Toshiyuki Asaki, Gang Wu, Yuka Iwamoto, Yoshitaka Yamaguchi, Chiyou Ni, John Engel, Naoki Tsuno, Aniket Patel, Xiaoming Zhou, Takuya Shintani, Kevin Brown, Tsuyoshi Hasegawa, Manjunath Shet, Yasuyoshi Iso, Akira Kato, Donald J. Kyle	Structure—Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management	J Med Chem. 2014 Aug 14;57(15):6781-94. doi: 10.1021/jm500818a. Epub 2014 Aug 1.
Lindsey C. Morris, Emily L. Days, Maxine Turney, Dehui Mi, Craig W. Lindsley, C. David Weaver, Kevin D. Niswender	A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors	J Biomol Screen. 2014 Feb 13;19(6):847-858. [Epub ahead of print]
Matthew F. Rouhier, Rene Raphemot, Jerod S. Denton, Peter M. Piermarini	Pharmacological Validation of an Inward-Rectifier Potassium (Kir) Channel as an Insecticide Target in the Yellow Fever MosquitoAedes aegypti	PLoS One. 2014 Jun 24;9(6):e100700. doi: 10.1371/journal.pone.0100700. eCollection 2014.
Michael P. Winters, Nalin Subasinghe, Mark Wall, Edward Beck, Michael R. Brandt, Michael F.A. Finley, Yi Liu, Mary Lou Lubin, Michael P. Neeper, Ning Qin, Christopher M. Flores, Zhihua Sui	Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel	Bioorg Med Chem Lett. 2014 May 1;24(9):2053-6. doi: 10.1016/j.bmcl.2014.03.062. Epub 2014 Mar 27.
Mikkel A. Rasmussen, Bjorn Holst, Zeynep Tumer, Mads G. Johnsen, Shuling Zhou, Tina C. Stummann, Poul Hyttel, Christian Clausen	Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage	Stem Cell Reports. 2014 Sep 9;3(3):404-13. doi: 10.1016/j.stemcr.2014.07.006. Epub 2014 Aug 21.
Mingfei Ji, Xubo Su, Xiaohong Su, Yingyi Chen, Wenkang Huang, Jian Zhang, Zhaobin Gao, Chuangang Li, Xuefeng Lu	Identification of Novel Compounds for Human Bitter Taste Receptors	Chem Biol Drug Des. 2014 Jul;84(1):63-74. doi: 10.1111/cbdd.12293. Epub 2014 Feb 28.
Nidhi Jalan-Sakrikar, Julie R. Field, Rebecca Klar, Margrith E. Mattmann, Karen J. Gregory, Rocio Zamorano, Darren W. Engers, Sean R. Bollinger, C. David Weaver, Emily L. Days, L. Michelle Lewis, Thomas J. Utley, Miguel Hurtado, Delphine Rigault, Francine Acher, Adam G. Walker, Bruce J. Melancon, Michael R. Wood, Craig W. Lindsley, P. Jeffrey Conn, Zixiu Xiang, Corey R. Hopkins, and Colleen M. Niswender	Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7	ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. doi: 10.1021/cn500153z. Epub 2014 Oct 9.
R. Benjamin Free, Lani S. Chun, Amy E. Moritz, Brittney N. Miller, Trevor B. Doyle, Jennie L. Conroy, Adrian Padron, Julie A. Meade, Jingbo Xiao, Xin Hu, Andres E. Dulcey, Yang Han, Lihua Duan, Steve Titus, Melanie Bryant-Genevier, Elena Barnaeva, Marc Ferrer, Jonathan A. Javitch, Thijs Beuming, Lei Shi, Noel T. Southall, Juan J. Marugan, David R. Sibley	Discovery and Characterization of a G Protein—Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor	Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22.
Rene Raphemot, Matthew F. Rouhier, Daniel R. Swale, Emily Days, C. David Weaver, Kimberly M. Lovell, Leah C. Konkel, Darren W. Engers, Sean F. Bollinger, Corey Hopkins, Peter M. Piermarini , Jerod S. Denton	Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels	PLoS One. 2014 Nov 6;9(11):e110772. doi: 10.1371/journal.pone.0110772. eCollection 2014.
Wendy J. Winchester, Katrina Gore, Sophie Glatt, Wendy Petit, Jennifer C. Gardiner, Kelly Conlon, Michael Postlethwaite, Pierre-Philippe Saintot, Sonia Roberts, James R. Gosset, Tomomi Matsuura, Mark D. Andrews, Paul A. Glossop, Michael J. Palmer, Nicola Clear, Susie Collins, Kevin Beaumont, David S. Reynolds	Inhibition of TRPM8 Channels Reduces Pain in the Cold Pressor Test in Humans	J Pharmacol Exp Ther. 2014 Nov;351(2):259-69. doi: 10.1124/jpet.114.216010. Epub 2014 Aug 14.
Zhiqiang Wang, Shimeng Liu, Miyo Kakizaki, Yuuki Hirose, Yukiko Ishikawa, Hiromasa Funato, Masashi Yanagisawa, Yonghao Yu, Qinghua Liu	Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway	J Biol Chem. 2014 Nov 14;289(46):31950-9. doi: 10.1074/jbc.M114.600015. Epub 2014 Oct 2.

2013

Authors	Title	Source
Andrew J. Storaska, Jian P. Mei, Meng Wu, Min Li, Susan M. Wade, Levi L. Blazer, Benita Sjogren, Corey R. Hopkins, Craig W. Lindsley, Zhihong Lin, Joseph J. Babcock, Owen McManus, Richard R. Neubig	Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay	Cell Signal. 2013 Dec;25(12):2848-55. doi: 10.1016/j.cellsig.2013.09.007. Epub 2013 Sep 14.
C Brenneis, K Kistner, M Puopolo, S Jo, DP Roberson, M Sisignano, D Segal, E J Cobos, B J Wainger, S Labocha, N Ferreiros, C von Hehn, J Tran, G Geisslinger, P W Reeh, B P Bean, C J Woolf	Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block	Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466.
Erica VanderPorten, Lauren Frick, Rebecca Turincio, Peter Thana, William LaMarr, Yichin Liu	Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors	Anal Biochem. 2013 Oct 15;441(2):115-22. doi: 10.1016/j.ab.2013.07.003. Epub 2013 Jul 16.
Florian P. M. Kohn	High Throughput Fluorescent Screening of Membrane Potential and Intracellular Calcium Concentration Under Variable Gravity Conditions	Microgravity Sci. Technol. 2013 April, Volume 25, Issue 2, pp 113-120. doi: 10.1007/s12217-012-9331-8
Hilde Lavreysen, Xavier Langlois, Abdel Ahnaou, Wilhelmus Drinkenburg, Paula te Riele, Ilse Biesmans, Ilse Van der Linden, Luc Peeters, Anton Megens, Cindy Wintmolders, Jose Maria Cid, Andres A. Trabanco, Jose Ignacio Andres, Frank M. Dautzenberg, Robert Lutjens, Gregor Macdonald, John R. Atack	Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782	J Pharmacol Exp Ther. 2013 Sep;346(3):514-27. doi: 10.1124/jpet.113.204990. Epub 2013 Jun 13.
Jason T. Manka, Alice L. Rodriguez, Ryan D. Morrison, Daryl F. Venable, Hyekyung P. Cho, Anna L. Blobaum, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte	Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1	Bioorg Med Chem Lett. 2013 Sep 15;23(18):5091-6. doi: 10.1016/j.bmcl.2013.07.029. Epub 2013 Jul 23.
Kentaro Ozawa, Akira T. Komatsubara, Yuhei Nishimura, Tomoyo Sawada, Hiroto Kawafune, Hiroki Tsumoto, Yuichi Tsuji, Jing Zhao, Yoji Kyotani, Toshio Tanaka, Ryosuke Takahashi, Masanori Yoshizumi	S-nitrosylation regulates mitochondrial quality control via activation of parkin	Sci Rep. 2013;3:2202. doi: 10.1038/srep02202.
Kentaro Takai, Yasunao Inoue, Yasuko Konishi, Atsushi Suwa, Yoshiharu Uruno, Harumi Matsuda, Tomokazu Nakako, Mutsuko Sakai, Hiroyuki Nishikawa, Gakuji Hashimoto, Takeshi Enomoto, Atsushi Kitamura, Yasuaki Uematsu, Akihiko Kiyoshi, Takaaki Sumiyoshi	Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M1 and M4 muscarinic acetylcholine receptors agonists	Bioorg Med Chem Lett. 2013 Aug 15;23(16):4644-7. doi: 10.1016/j.bmcl.2013.06.013. Epub 2013 Jun 13.
Kimberly M. Lovell, Andrew S. Felts, Alice L. Rodriguez, Daryl F. Venable, Hyekyung P. Cho, Ryan D. Morrison, Frank W. Byers, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte	N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats	Bioorg Med Chem Lett. 2013 Jul 1;23(13):3713-8. doi: 10.1016/j.bmcl.2013.05.020. Epub 2013 May 17.
Lani S. Chun, R. Benjamin Free, Trevor B. Doyle, Xi-Ping Huang, Michele L. Rankin, David R. Sibley	D1-D2 Dopamine Receptor Synergy Promotes Calcium Signaling via Multiple Mechanisms	Mol Pharmacol. 2013 Aug;84(2):190-200. doi: 10.1124/mol.113.085175. Epub 2013 May 16.
Mamoru Tasakia, Miki Kobayashi, Yoshiyuki Tenda, Susumu Tsujimoto, Shoko Nakazato, Mako Numazaki, Yasuno Hirano, Hiroshi Matsuda, Tadashi Terasaka, Yasuhiro Miyao, Yasuaki Shimizu, Yoshitaka Hirayama	Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of “chemoattractant receptor homologous molecule expressed on Th2 cells” (CRTH2)	Eur J Pharm Sci. 2013 Jun 14;49(3):434-40. doi: 10.1016/j.ejps.2013.04.017. Epub 2013 Apr 24.
Paul H. Tewson, Anne Marie Quinn, Thomas E. Hughes	A Multiplexed Fluorescent Assay for Independent Second-Messenger Systems Decoding GPCR Activation in Living Cells	J Biomol Screen. 2013 Aug;18(7):797-806. doi: 10.1177/1087057113485427. Epub 2013 Apr 11.
Rene Raphemot, C. David Weaver, Jerod S. Denton	High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels	J Vis Exp. 2013 Jan 27;(71). pii: 4209. doi: 10.3791/4209.
Rene Raphemot, Matthew F. Rouhier, Rocco D. Gogliotti, Kimberly M. Lovell, Rebecca M. Hine, Dhairyasheel Ghosalkar, Anthony Longo, Klaus W. Beyenbach, Jerod S. Denton, Peter M. Piermarini	Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels	PLoS One. 2013 May 29;8(5):e64905. doi: 10.1371/journal.pone.0064905. Print 2013.
Samarjit Patnaik, Juan J. Marugan, Ke Liu, Wei Zheng, Noel Southall, Seameen J. Dehdashti, Annika Thorsell, Markus Heilig, Lauren Bell, Michelle Zook, Bob Eskay, Kyle R. Brimacombe, Christopher P. Austin	Structure—Activity Relationship of Imidazopyridinium Analogues as Antagonists of Neuropeptide S Receptor	J Med Chem. 2013 Nov 27;56(22):9045-56. doi: 10.1021/jm400904m. Epub 2013 Nov 11.
Sandra Santulli-Marotto, Jamie Fisher, Theodore Petley, Ken Boakye, Tadas Panavas, Jennifer Luongo, Karl Kavalkovich, Michael Rycyzyn, Bingyuan Wu, Lester Gutshall, Ana Coelho, Cory M. Hogaboam, Mary Ryan	Surrogate Antibodies That Specifically Bind and Neutralize CCL17 But Not CCL22	Monoclon Antib Immunodiagn Immunother. 2013 Jun;32(3):162-71. doi: 10.1089/mab.2012.0112.
Sandra Santulli-Marotto, Ken Boakye, Eilyn Lacy, Sheng-Jiun Wu, Jennifer Luongo, Karl Kavalkovich, Ana Coelho, Cory M. Hogaboam, Mary Ryan	Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung	PLoS One. 2013 Dec 5;8(12):e81465. doi: 10.1371/journal.pone.0081465. eCollection 2013.
Sebastien Hannedouche, Valerie Beck, Juliet Leighton-Davies, Martin Beibel, Guglielmo Roma, Edward J. Oakeley, Vincent Lannoy, Jerome Bernard, Jacques Hamon, Samuel Barbieri, Inga Preuss, Marie-Christine Lasbennes, Andreas W. Sailer, Thomas Suply, Klaus Seuwen, Christian N. Parker, Frederic Bassilana	Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells	J Biol Chem. 2013 Sep 20;288(38):27434-43. doi: 10.1074/jbc.M113.497214. Epub 2013 Aug 12.
Shoichiro Ozaki, Akinobu Z. Suzuki, Peter O. Bauer, Etsuko Ebisui, Katsuhiko Mikoshiba	2-Aminoethyl diphenylborinate (2-APB) analogues: Regulation of Ca2+ signaling	Biochem Biophys Res Commun. 2013 Nov 15;441(2):286-90. doi: 10.1016/j.bbrc.2013.08.102. Epub 2013 Sep 11.
Summer E. Young, Matthew T. Duvernay, Michael L. Schulte, Craig W. Lindsley, Heidi E. Hamm	Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets	PLoS One. 2013 Jun 11;8(6):e65528. doi: 10.1371/journal.pone.0065528. Print 2013.
Susan J. Ramos-Hunter, Darren W. Engers, Kristian Kaufmann, Yu Du, Craig W. Lindsley, C. David Weaver, Gary A. Sulikowski	Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators	Bioorg Med Chem Lett. 2013 Sep 15;23(18):5195-8. doi: 10.1016/j.bmcl.2013.07.002. Epub 2013 Jul 18.
Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn, J. Scott Daniels	Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism	Drug Metab Dispos. 2013 Sep;41(9):1703-14. doi: 10.1124/dmd.113.052084. Epub 2013 Jul 2.

2012

Authors	Title	Source
Bo-Hye Im, Hyewhon Rhim	GABAB receptor-mediated ERK1/2 phosphorylation via a direct interaction with CaV1.3 channels	Neurosci Lett. 2012 Mar 28;513(1):89-94. doi: 10.1016/j.neulet.2012.02.014. Epub 2012 Feb 14.
Caroline Chambon, Claudia Jatzke, Nico Wegener, Andreas Gravius, Wojciech Danysz	Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication	Eur J Pharmacol. 2012 Dec 15;697(1-3):73-80. doi: 10.1016/j.ejphar.2012.10.011. Epub 2012 Oct 17.
Christina Molck, Kasper Harpsoe, David E. Gloriam, Rasmus P. Clausen, Ulf Madsen, Lars O. Pedersen, Hermogenes N. Jimenez, Soren M. Nielsen, Jesper M. Mathiesen, Hans Brauner-Osborne	Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators	Mol Pharmacol. 2012 Nov;82(5):929-37. doi: 10.1124/mol.112.078808. Epub 2012 Aug 16.
DAVID C. RINKER, PATRICK L. JONES, R. JASON PITTS, MICHAEL RUTZLER, GRAY CAMP, LUJUAN SUN, PINGXI XU, DANIEL C. DORSET, DAVID WEAVER, LAURENCE J. ZWIEBEL	Novel high-throughput screens of Anopheles gambiae odorant receptors reveal candidate behaviour-modifying chemicals for mosquitoes	Physiol Entomol. 2012;37:33-41 doi: 10.1111/j.1365-3032.2011.00821.x
Dinesh Puppala, Leon P. Collis, Sunny Z. Sun, Vinicius Bonato, Xian Chen, Blake Anson, Mathew Pletcher, Bernard Fermini, Sandra J. Engle	Comparative Gene Expression Profiling in Human-Induced Pluripotent Stem Cell—Derived Cardiocytes and Human and Cynomolgus Heart Tissue	Toxicol Sci. 2013 Jan;131(1):292-301. doi: 10.1093/toxsci/kfs282. Epub 2012 Sep 14.
Franck Potet, Amanda N. Lorinc, Sebastien Chaigne, Corey R. Hopkins, Raghav Venkataraman, Svetlana Z. Stepanovic, L. Michelle Lewis, Emily Days, Veniamin Y. Sidorov, Darren W. Engers, Beiyan Zou, David Afshartous, Alfred L. George Jr., Courtney M. Campbell, Jeffrey R. Balser, Min Li, Franz J. Baudenbacher, Craig W. Lindsley, C. David Weaver, Sabina Kupershmidt	Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-a-go-go-related Gene (hERG)-related Drug-induced Arrhythmias	J Biol Chem. 2012 Nov 16;287(47):39613-25. doi: 10.1074/jbc.M112.380162. Epub 2012 Oct 2.
Heinz Ruffner, Joelle Sprunger, Olga Charlat, Juliet Leighton-Davies, Bianka Grosshans, Adrian Salathe, Svenja Zietzling, Valerie Beck, Maxime Therier, Andrea Isken, Yang Xie, Yue Zhang, Huaixiang Hao, Xiaoying Shi, Dong Liu, Qinhui Song, Ieuan Clay, Gabriele Hintzen, Jan Tchorz, Laure C. Bouchez, Gregory Michaud, Peter Finan, Vic E. Myer, Tewis Bouwmeester, Jeff Porter, Marc Hild, Fred Bassilana, Christian N. Parker, Feng Cong	R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5	PLoS One. 2012;7(7):e40976. doi: 10.1371/journal.pone.0040976. Epub 2012 Jul 16.
India C. Severin, Adriano L.S. Souza, Jonathan H. Davis, Najia Musolino, Matthias Mack, Christine A. Power, Amanda E.I. Proudfoot	Properties of 7ND—CCL2 are modulated upon fusion to Fc	Protein Eng Des Sel. 2012 May;25(5):213-22. doi: 10.1093/protein/gzs008. Epub 2012 Mar 2.
Jack Bergman, Rebecca A. Roof, Cheryse A. Furman, Jennie L. Conroy, Nancy K. Mello, David R. Sibley, Phil Skolnick	Modification of cocaine self-administration by buspirone (busparR): potential involvement of D3 and D4 dopamine receptors	Int J Neuropsychopharmacol. 2013 Mar;16(2):445-58. doi: 10.1017/S1461145712000661. Epub 2012 Jul 25.
James M. Salovich, Paige N. Vinson, Douglas J. Sheffler, Atin Lamsal, Thomas J. Utley, Anna L. Blobaum, Thomas M. Bridges, Uyen Le, Carrie K. Jones, Michael R. Wood, J. Scott Daniels, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley, Corey R. Hopkins	Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor	Bioorg Med Chem Lett. 2012 Aug 1;22(15):5084-8. doi: 10.1016/j.bmcl.2012.05.109. Epub 2012 Jun 6.
Jingbo Xiao, R. Benjamin Free, Elena Barnaeva, Jennie Conroy, Trevor Doyle, Marthe Bryant-Genevier, Mercedes K. Taylor, Noel Southall, Xin Hu, Marc Ferrer, Steve Titus, Wei Zheng, David R. Sibley, Juan J. Marugan.	Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists	Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 25 [updated 2013 Sep 03].
Jung-eun Park, Wan Keun Ji, Jae Wan Jang, Ae Nim Pae, Keehyun Choi, Ki Hang Choi, Jahyo Kang, Eun Joo Roh	Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers	Bioorg Med Chem Lett. 2013 Mar 15;23(6):1887-90. doi: 10.1016/j.bmcl.2012.12.072. Epub 2013 Jan 12.
Jutty Rajan Prashanth, Richard J. Lewis, Sebastien Dutertre	Towards an integrated venomics approach for accelerated conopeptide discovery	Toxicon. 2012 Sep 15;60(4):470-7. doi: 10.1016/j.toxicon.2012.04.340. Epub 2012 Apr 28.
Linjie Chen, Lili Jin, Naiming Zhou	An update of novel screening methods for GPCR in drug discovery	Expert Opin Drug Discov. 2012 Sep;7(9):791-806. doi: 10.1517/17460441.2012.699036. Epub 2012 Jun 21.
Mohammed Akhlaq; Elizabeth M. Rosethorne; Afrah Sattikar; Toby C. Kent	The Use of Cold Plasma Technology to Reduce Carryover in Screening Assays	J Lab Autom. 2013 Aug;18(4):269-75. doi: 10.1177/2211068212457780. Epub 2012 Sep 14.
Nalin L. Subasinghe, Mark J. Wall, Michael P. Winters, Ning Qin, Mary Lou Lubin, Michael F.A. Finley, Michael R. Brandt, Michael P. Neeper, Craig R. Schneider, Raymond W. Colburn, Christopher M. Flores, Zhihua Sui	A novel series of pyrazolylpiperidine N-type calcium channel blockers	Bioorg Med Chem Lett. 2012 Jun 15;22(12):4080-3. doi: 10.1016/j.bmcl.2012.04.075. Epub 2012 May 2.
Roman Hudec, Kozo Hamada, Katsuhiko Mikoshiba	A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples	Anal Biochem. 2013 Feb 15;433(2):95-101. doi: 10.1016/j.ab.2012.10.014. Epub 2012 Oct 15.
Shen Yin, Rocio Zamorano, P. Jeffrey Conn, Colleen M. Niswender	Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors	Neuropharmacology. 2013 Mar;66:122-32. doi: 10.1016/j.neuropharm.2012.03.003. Epub 2012 Mar 9.
Shuzo Watanabe	Discovery of voltage-gated sodium-channel blockers for the treatment of neuropathic pain	Nihon Yakurigaku Zasshi. 2012 Nov;140(5):201-5. doi: 10.1254/fpj.140.201
Wenthur C, Daniels JS, Morrison R, Engers JL, Niswender CM, Conn PJ, Lindsley CW.	Development of a Second Generation mGlu3 NAM Probe	Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 10 [updated 2013 Mar 22].
Yueming Zheng, Xuejing Zhu, Pingzheng Zhou, Xi Lan, Haiyan Xu, Min Li, Zhaobing Gao	Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants	PLoS One. 2012;7(12):e51820. doi: 10.1371/journal.pone.0051820. Epub 2012 Dec 12.

2011

Authors	Title	Source
Atsushi Inayoshi, Yoshiyuki Sugimoto, Jun Funahashi, Saori Takahashi, Masahiro Matsubara, Hideaki Kusaka	Mechanism underlying the block of human Cav3.2 T-type Ca2+ channels by benidipine, a dihydropyridine Ca2+ channel blocker	Life Sci. 2011 May 9;88(19-20):898-907. doi: 10.1016/j.lfs.2011.03.019. Epub 2011 Apr 3.
C. David Weaver	Triple-Addition Assay Protocols for Detecting and Characterizing Modulators of Seven-Transmembrane Receptors	Curr Protoc Chem Biol. 2011 Sep 1;3(3):119-40. doi: 10.1002/9780470559277.ch110060.
Carrie K. Jones, Michael Bubser, Analisa D. Thompson, Jonathan W. Dickerson, Nathalie Turle-Lorenzo, Marianne Amalric, Anna L. Blobaum, Thomas M. Bridges, Ryan D. Morrison, Satyawan Jadhav, Darren W. Engers, Kimberly Italiano, Jacob Bode, J. Scott Daniels, Craig W. Lindsley, Corey R. Hopkins, P. Jeffrey Conn, Colleen M. Niswender	The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with L-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease	J Pharmacol Exp Ther. 2012 Feb;340(2):404-21. doi: 10.1124/jpet.111.187443. Epub 2011 Nov 16.
Curtis A. Thorne, Bonnie Lafleur, Michelle Lewis, Alison J. Hanson, Kristin K. Jernigan, David C. Weaver, Kari A. Huppert, Tony W. Chen, Chonlarat Wichadiit, Christopher S. Cselenyi, Emilios Tahinci, Kelly C. Meyers, Emily Waskow, Darren Orton, Adrian Salic, Laura A. Lee, David J. Robbins, Stacey S. Huppert, Ethan Lee	A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts	J Biomol Screen. 2011 Oct;16(9):995-1006. doi: 10.1177/1087057111416657. Epub 2011 Aug 21.
Gaelle Dintilhac, Deniz Arslan, Sebastien Dilly, Laurence Danober, Iuliana Botez, Pierre Lestage, Bernard Pirotte, Pascal de Tullio	New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors	Med. Chem. Commun., 2011,2, 509-523 doi: 10.1039/C1MD00069A
Haibo Yu, Meng Wu, Corey Hopkins, Julie Engers, Steve Townsend, Craig Lindsley, Owen B McManus, Min Li.	A small molecule activator of KCNQ2 and KCNQ4 channels.	Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2011 Mar 29 [updated 2013 Feb 28].
Haibo Yu, Kaiping Xu, Beiyan Zou, Meng Wu, Owen B. McManus, Julie Le Engers, Yiu-Yin Cheung, James M. Salovich, Corey R. Hopkins, Craig W. Lindsley, and Min Li.	Identification of a novel, small molecule inhibitor of KCNQ2 channels	Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2011 Oct 28 [updated 2013 Feb 25].
Haibo Yu, Zhihong Lin, Kaiping Xu, Xiaofang Huang, Shunyou Long, Meng Wu, Owen B. McManus, Julie Le Engers, Margrith E. Mattmann, Darren W. Engers, Uyen M. Le, Craig W. Lindsley, Corey R. Hopkins, Min Li.	Identification of a novel, small molecule activator of KCNQ1 channels	Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2011 Dec 16 [updated 2013 Mar 7].
Jacques Pantela, Savannah Y. Williams, Dehui Mi, Julien Sebag, Jackie D. Corbin, C. David Weaver, Roger D. Cone	Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay	Eur J Pharmacol. 2011 Jun 11;660(1):139-47. doi: 10.1016/j.ejphar.2011.01.031. Epub 2011 Feb 4.
Jinghai Song, Hiroshi Hagiya, Haruto Kurata, Hirotaka Mizuno, Toshinori Ito	Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation	Transpl Immunol. 2012 Mar;26(2-3):163-70. doi: 10.1016/j.trim.2011.12.005. Epub 2011 Dec 14.
Jun Chen, Regina M. Reilly, Philip R. Kym, and Shailen Joshi.	In Vitro and in Vivo Assays for the Discovery of Analgesic Drugs Targeting TRP Channels	In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press; 2011. Chapter 18.
Marianthi Papakosta, Carine Dalle, Alison Haythornthwaite, Lishuang Cao, Edward B. Stevens, Gillian Burgess, Rachel Russell, Peter J. Cox, Stephen C. Phillips, Christian Grimm	The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation	J Biol Chem. 2011 Nov 11;286(45):39663-72. doi: 10.1074/jbc.M111.273581. Epub 2011 Sep 12.
Menghang Xia, Sampada A. Shahane, Ruili Huang, Steven A. Titus, Enoch Shum, Yong Zhao, Noel Southall, Wei Zheng, Kristine L. Witt, Raymond R. Tice, Christopher P. Austin	Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels	Toxicol Appl Pharmacol. 2011 May 1;252(3):250-8. doi: 10.1016/j.taap.2011.02.016. Epub 2011 Feb 26.
Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender, Zixiu Xiang, J Scott Daniels, Crag W Lindsley, C David Weaver, P Jeffrey Conn	Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of mGlu5 in Regulating CNS Function	Mol Pharmacol. 2012 Feb;81(2):120-33. doi: 10.1124/mol.111.075184. Epub 2011 Oct 21.
Peter R McDonald, Anuradha Roy, Rathnam Chaguturu	The University of Kansas High-Throughput Screening Laboratory. Part II: enabling collaborative drug-discovery partnerships through cutting-edge screening technology	Future Med Chem. 2011 Jul;3(9):1101-10. doi: 10.4155/fmc.11.84.
Rene Raphemot, Daniel F. Lonergan, Thuy T. Nguyen, Thomas Utley, L. Michelle Lewis, Rishin Kadakia, C. David Weaver, Rocco Gogliotti, Corey Hopkins, Craig W. Lindsley, Jerod S. Denton	Discovery, characterization, and structure—activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X, and Kir7.1	Front Pharmacol. 2011 Nov 30;2:75. doi: 10.3389/fphar.2011.00075. eCollection 2011.
Thierry Ferain, Hamid Hoveyda, Frederic Ooms, Dominique Schols, Jerome Bernard, Graeme Fraser	Agonist-Induced Internalization of CC Chemokine Receptor 5 as a Mechanism to Inhibit HIV Replication	J Pharmacol Exp Ther. 2011 Jun;337(3):655-62. doi: 10.1124/jpet.111.179622. Epub 2011 Mar 9.
Xinmin Xie, John T. Brogan, Michael L. Schulte, Debbie Mi, Haibo Yu, Eric S. Dawson, Min Li, Owen McManus, Julie Engers, L. Michelle Lewis, Analisa Thompson, Carrie K. Jones, C. David Weaver, Craig W. Lindsley.	Scaffold Hopping Affords a Highly Selective in vitro and in vivo T-Type Calcium Inhibitor Probe Free From IP Issues	Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2011 Mar 31 [updated 2013 Mar 22].
Yasuaki Sanada, Tsunekazu Mizushima, Yasuyuki Kai, Junichi Nishimura, Hiroshi Hagiya, Haruto Kurata, Hirotaka Mizuno, Etsuko Uejima, Toshinori Ito	Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis	PLoS One. 2011;6(9):e23933. doi: 10.1371/journal.pone.0023933. Epub 2011 Sep 8.

2010

Authors	Title	Source
Ke Liu, Noel Southall, Steve A. Titus, James Inglese, Robert L. Eskay, Paul Shinn, Christopher P. Austin, Markus A. Heilig and Wei Zheng.	A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists	Assay Drug Dev Technol. 2010 Jun;8(3):367-79.
Brad P. Barnett, Yousang Hwang, Martin S. Taylor, Henriette Kirchner, Paul T. Pfluger, Vincent Bernard, Yu-yi Lin, Erin M. Bowers, Chandrani Mukherjee, Woo-Jin Song, Patti A. Longo, Daniel J. Leahy, Mehboob A. Hussain, Matthias H. Tschop, Jef D. Boeke and Philip A. Cole.	Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor	Science 17 December 2010: Vol. 330 no. 6011 pp. 1689-1692.
Evan P Lebois, Thomas M Bridges, L. Michelle Lewis, Eric S Dawson, Alexander S. Kane, Zixiu Xiang, Satyawan B Jadhav, Huiyong Yin, J. Phillip Kennedy, Jens Meiler, Colleen M. Niswender, Carrie K Jones, P Jeffrey Conn, C David Weaver, and Craig W Lindsley.	Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system	ACS Chem Neurosci. 2010; 1(2): 104-121.
Zhaobing Gao, Tangzhi Zhang, Meng Wu, Qiaojie Xiong, Haiyan Sun, Yinan Zhang, Liansuo Zu, Wei Wang and Min Li	Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions	September 3, 2010 The Journal of Biological Chemistry, 285, 28322-28332.
Jinliang Sui, Shakira Cotard, Jennifer Andersen, Ping Zhu, Jane Staunton, Margaret Lee, and Stephen Lin.	Optimization of a Yellow Fluorescent Protein-Based Iodide Influx High-Throughput Screening Assay for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators	ASSAY and Drug Development Technologies. December 2010, 8(6): 656-668. doi:10.1089/adt.2010.0312.
Stephen Lin, Jinliang Sui, Shakira Cotard, Brenda Fung, Jennifer Andersen, Ping Zhu, Najib El Messadi, Joseph Lehar, Margaret Lee, and Jane Staunton.	Identification of Synergistic Combinations of F508del Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators	ASSAY and Drug Development Technologies. December 2010, 8(6): 669-684. doi:10.1089/adt.2010.0313.

2009

Authors	Title	Source
Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD.	Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2	Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. Epub 2009 Mar 11.
Irukayama-Tomobe Y, Tanaka H, Yokomizo T, Hashidate-Yoshida T, Yanagisawa M, Sakurai T.	Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B	Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. Epub 2009 Feb 23.
Lewis LM, Bhave G, Chauder BA, Banerjee S, Lornsen KA, Redha R, Fallen K, Lindsley CW, Weaver CD, Denton JS.	High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1	Mol Pharmacol. 2009 Nov;76(5):1094-103. Epub 2009 Aug 25.
Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ.	Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity	Mol Pharmacol. 2009 Mar;75(3):577-88. Epub 2008 Dec 1.
Sheffler DJ, Williams R, Bridges TM, Xiang Z, Kane AS, Byun NE, Jadhav S, Mock MM, Zheng F, Lewis LM, Jones CK, Niswender CM, Weaver CD, Lindsley CW, Conn PJ.	A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning	Mol Pharmacol. 2009 Aug;76(2):356-68. Epub 2009 Apr 30.
Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ.	A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning	J Neurosci. 2009 Nov 11;29(45):14271-86.
Bridges TM, Marlo JE, Niswender CM, Jones CK, Jadhav SB, Gentry PR, Plumley HC, Weaver CD, Conn PJ, Lindsley CW.	Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins	J Med Chem. 2009 Jun 11;52(11):3445-8.
Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR.	Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)	J Med Chem. 2009 Jul 23;52(14):4115-8.
Sharma S, Kedrowski J, Rook JM, Smith RL, Jones CK, Rodriguez AL, Conn PJ, Lindsley CW.	Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines	J Med Chem. 2009 Jul 23;52(14):4103-6.
Wise H, Abel PW, Cawkill D.	Use of reduced temperature cell pausing to enhance flexibility of cell-based assays	J Biomol Screen. 2009 Jul;14(6):716-22. Epub 2009 May 21.
Mori T, Itami S, Yanagi T, Tatara Y, Takamiya M, Uchida T.	Use of a real-time fluorescence monitoring system for high-throughput screening for prolyl isomerase inhibitors	J Biomol Screen. 2009 Apr;14(4):419-24.
Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW.	Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe	Curr Top Med Chem. 2009;9(13):1217-26.
Kim Y, Kang S, Lee JY, Rhim H.	High throughput screening assay of alpha(1G) T-type Ca2+ channels and comparison with patch-clamp studies	Comb Chem High Throughput Screen. 2009 Mar;12(3):296-302.
Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR.	Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)	Bioorg Med Chem Lett. 2009 Sep 1;19(17):4967-70. Epub 2009 Jul 18.
Rodriguez AL, Williams R, Zhou Y, Lindsley SR, Le U, Grier MD, Weaver CD, Conn PJ, Lindsley CW.	Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype	Bioorg Med Chem Lett. 2009 Jun 15;19(12):3209-13. Epub 2009 May 3.
Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW.	Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead	Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6. Epub 2008 Dec 25.
Felts AS, Saleh SA, Le U, Rodriguez AL, Weaver CD, Conn PJ, Lindsley CW, Emmitte KA.	Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5	Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.
Zhou Y, Rodriguez AL, Williams R, Weaver CD, Conn PJ, Lindsley CW.	Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS	Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6. Epub 2009 Oct 28.
Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W.	A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel	Anal Biochem. 2009 Nov 1;394(1):30-8. Epub 2009 Jul 5.
Lin Tian, S. Andrew Hires, Tianyi Mao, Daniel Huber, M. Eugenia Chiappe, Sreekanth H. Chalasani, Leopoldo Petreanu, Jasper Akerboom, Sean A. McKinney, Eric R. Schreiter, Cornelia I. Bargmann, Vivek Jayaraman, Karel Svoboda, and Loren L. Looger	Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators	"Nat Methods. 2009 December; 6(12): 875-881.Published online 2009 November 8. doi: 10.1038/nmeth.1398"

2008

Authors	Title	Source
Taniguchi Y, Tonai-Kachi H, Shinjo K.	5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist	Pharmacology. 2008;82(4):245-9. Epub 2008 Sep 26.
Ayala JE, Niswender CM, Luo Q, Banko JL, Conn PJ.	Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated	Neuropharmacology. 2008 Apr;54(5):804-14. Epub 2007 Dec 24.
Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ.	An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission	Nat Chem Biol. 2008 Jan;4(1):42-50. Epub 2007 Dec 2.
Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ.	Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4	Mol Pharmacol. 2009 Mar;75(3):577-88. Epub 2008 Dec 1.
Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD.	A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors	Mol Pharmacol. 2008 Apr;73(4):1213-24. Epub 2008 Jan 2.
Kobayashi K, Nishizawa Y, Sawada K, Ogura H, Miyabe M.	K(+)-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons	J Pharmacol Sci. 2008 Dec;108(4):517-28. Epub 2008 Dec 11.
Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ.	Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats	J Neurosci. 2008 Oct 8;28(41):10422-33.
Akasofu S, Sawada K, Kosasa T, Hihara H, Ogura H, Akaike A.	Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine	Eur J Pharmacol. 2008 Jul 7;588(2-3):189-97. Epub 2008 Apr 13.
Gunnet JW, Wines P, Xiang M, Rybczynski P, Andrade-Gordon P, de Garavilla L, Parry TJ, Cheung WM, Minor L, Demarest KT, Maryanoff BE, Damiano BP.	Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonis	Eur J Pharmacol. 2008 Aug 20;590(1-3):333-42. Epub 2008 Jun 7.
Kim HJ, Yun HM, Kim T, Nam G, Roh EJ, Kostenis E, Choo HY, Pae AN, Rhim H.	Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins	Comb Chem High Throughput Screen. 2008 May;11(4):316-24.
Niswender CM, Lebois EP, Luo Q, Kim K, Muchalski H, Yin H, Conn PJ, Lindsley CW.	Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators	Bioorg Med Chem Lett. 2008 Oct 15;18(20):5626-30. Epub 2008 Aug 29.
Lewis LM, Sheffler D, Williams R, Bridges TM, Kennedy JP, Brogan JT, Mulder MJ, Williams L, Nalywajko NT, Niswender CM, Weaver CD, Conn PJ, Lindsley CW.	Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists	Bioorg Med Chem Lett. 2008 Feb 1;18(3):885-90. Epub 2008 Jan 4.

2007

Authors	Title	Source
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM.	TRPA1 mediates formalin-induced pain	Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30. Epub 2007 Aug 8.
Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, Tamagnan GD, Conn PJ.	A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors	J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. Epub 2007 Apr 6.
Song F, Lu S, Gunnet J, Xu JZ, Wines P, Proost J, Liang Y, Baumann C, Lenhard J, Murray WV, Demarest KT, Kuo GH.	Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists	J Med Chem. 2007 Jun 14;50(12):2807-17. Epub 2007 May 15.
Cassutt KJ, Orsini MJ, Abousleiman M, Colone D, Tang W.	Identifying nonselective hits from a homogeneous calcium assay screen	J Biomol Screen. 2007 Mar;12(2):285-7. Epub 2007 Feb 8.
Yun HM, Kim S, Kim HJ, Kostenis E, Kim JI, Seong JY, Baik JH, Rhim H.	The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn	J Biol Chem. 2007 Feb 23;282(8):5496-505. Epub 2006 Dec 22.
Park JH, Choi JK, Lee E, Lee JK, Rhim H, Seo SH, Kim Y, Doddareddy MR, Pae AN, Kang J, Roh EJ.	Lead discovery and optimization of T-type calcium channel blockers	Bioorg Med Chem. 2007 Feb 1;15(3):1409-19. Epub 2006 Nov 10.

2006

Authors	Title	Source
Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J.	A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice	Proc Natl Acad Sci U S A. 2006 May 9;103(19):7438-43. Epub 2006 Apr 28.
Taniguchi Y, Tonai-Kachi H, Shinjo K.	Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35	FEBS Lett. 2006 Sep 18;580(21):5003-8. Epub 2006 Aug 17.
FEBS Lett. 2006 Sep 18;580(21):5003-8. Epub 2006 Aug 17.	Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl-d-aspartate (NMDA) toxicity	Eur J Pharmacol. 2006 Jan 20;530(3):215-22.
Tang Y, Zhou L, Gunnet JW, Wines PG, Cryan EV, Demarest KT.	Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A	Biochem Biophys Res Commun. 2006 Jun 23;345(1):29-37. Epub 2006 Apr 25.

2005

Authors	Title	Source
Nakae K, Hayashi F, Hayashi M, Yamamoto N, Iino T, Yoshikawa S, Gupta J.	Functional role of prostacyclin receptor in rat dorsal root ganglion neurons	Neurosci Lett. 2005 Nov 18;388(3):132-7.
Rodriguez AL, Nong Y, Sekaran NK, Alagille D, Tamagnan GD, Conn PJ.	A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators	Mol Pharmacol. 2005 Dec;68(6):1793-802. Epub 2005 Sep 9.
Qiao SW, Piper J, Haraldsen G, Oynebraten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM.	Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease	J Immunol. 2005 Feb 1;174(3):1657-63.
Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J.	SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice	J Biol Chem. 2005 Nov 11;280(45):37669-80. Epub 2005 Sep 7.

2004

Authors	Title	Source
Inbe H, Watanabe S, Miyawaki M, Tanabe E, Encinas JA.	Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine	J Biol Chem. 2004 May 7;279(19):19790-9. Epub 2004 Mar 4.
Suga H, Takeda S, Haga T, Okamura M, Takao K, Tatemoto K.	Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Galpha16 fusion proteins	J Biochem. 2004 May;135(5):605-13.

2003

Authors	Title	Source
Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M.	Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation	J Biol Chem. 2003 Jul 11;278(28):25481-9. Epub 2003 Apr 23.

2002

Authors	Title	Source
Le Poul E, Hisada S, Mizuguchi Y, Dupriez VJ, Burgeon E, Detheux M.	Adaptation of aequorin functional assay to high throughput screening	J Biomol Screen. 2002 Feb;7(1):57-65.
Sumichika H, Sakata K, Sato N, Takeshita S, Ishibuchi S, Nakamura M, Kamahori T, Ehara S, Itoh K, Ohtsuka T, Ohbora T, Mishina T, Komatsu H, Naka Y.	Identification of a potent and orally active non-peptide C5a receptor antagonist	J Biol Chem. 2002 Dec 20;277(51):49403-7. Epub 2002 Oct 15.

2001

Authors	Title	Source
Kawamoto T, Kimura H, Kusumoto K, Fukumoto S, Shiraishi M, Watanabe T, Sawada H.	Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559	Eur J Pharmacol. 2001 May 18;420(1):1-8.
Maeda K, Yoshimura K, Shibayama S, Habashita H, Tada H, Sagawa K, Miyakawa T, Aoki M, Fukushima D, Mitsuya H.	Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5	J Biol Chem. 2001 Sep 14;276(37):35194-200. Epub 2001 Jul 13.

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