Life Photonics  - Bioscience

Discovering and applying the mechanisms of life, from molecules to cells


Since the first study of cells 350 years ago, there has been an enormous growth in our understanding of biology. Today this knowledge benefits us in countless ways, for example through applications in regenerative medicine or novel methods in cancer diagnosis and treatment. But even with such advances, there are still many mysteries hidden in the roughly 60 trillion cells that make up our bodies. In our Life Photonics research, we use some of our exclusive technology to shed light on these mysteries. The technology is used to realize biological mechanisms on cellular and molecular levels. It is our hope that what we learn will find application in diverse areas, including medicine, healthcare, and green technology.


Reflection-type quantitative phase microscope

Reflection-type quantitative phase microscope

Detecting differentiated cells in the stem cells
To tell the difference between pluripotent stem cells and differentiated cells, we have developed a reflection-type quantitative phase microscopy. Our 3D imaging capability also helps us observe intercellular communication.

Label-free 3D phase-imaging flow cytometer

Phase imaging flowcytometer

Revealing the mechanism of cancer metastasis
It is said that circulating tumor cells (CTCs) play a role of cancer metastasis. However, nobody has yet demonstrated the mechanism. To reveal it, we are developing a way to detect and remove CTCs in the bloodstream.

Optical torque wrench

Optical torque wrench

Elucidating the source of life energy
To investigate the source of energy in life, we apply Laguerre Gaussian beams to clarify the revolution property of a "single-molecule motor" that has the function of conversion between chemical and mechanical energies in animal cells.

Photo-regulation of intracellular cAMP: promising tool for medical science

Regulation of cell signaling by light

Regulation of cell signaling by light
cAMP is a major signaling molecule which induces medical events in human cells. By employing a microbial photoreceptor, we control cAMP-generation in the cells with light. Hopefully such photoregulation of the cell signaling will serve a new prospect in molecular medicine.

Transmission-type quantitative phase microscope


Simple and easy-to-use quantitative cell observation
Quantitative phase microscopes are capable of imaging the optical thickness of cells to allow observing the morphological changes and movement of various cells.

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