Proteins are essential for most biological processes and exist in the cell in a dynamic state: changing in abundance, location, and in the way they interact with other proteins based on specific cellular stimuli. Modulating these aspects of cellular protein dynamics presents an interesting modality for drug development efforts, requiring assay systems that allow for protein kinetics to be studied in live cells and in high-throughput workflows in order accurately identify candidate compounds with the intended biological effect.
Here we will present bioluminescent assay solutions that allow for quantitative, real-time measurement of changing protein dynamics in live cells and demonstrate specific examples of modulating protein:protein interactions and protein abundance on relevant pharmacological targets using high-throughput plate formats.
Ph.D., Sr. Product Manager, Promega Corporation, Cellular Reporters Group
|Event Name||Webinar: Solutions for live-cell measurement of intracellular protein dynamics|
|Schedule||June 29, 2021|
|Venue||Virtual: 16:30 - 17:20 CET|
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