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SC light source

Application example: Brain neuronal imaging | Supercontinuum light source

 

Brain neuronal imaging with SD-OCM

The use of a broadband light source in the 1700 nm band enables high-resolution imaging of deep, highly scattered biological tissue. In particular, SD-OCM (spectral domain - optical coherence microscopy) enables non-invasive deep brain neuronal imaging without craniotomy, and has been applied to in-vivo observation of Alzheimer's lesions.

Measurement system

Sensitivity roll-off in air

Axial resolution in air

Result

 

Provided by Jun Zhu and Vivek J. Srinivasan (University of California Davis)

References

Authors
Title
Source
Jun Zhu and Vivek J. Srinivasan In vivo mouse brain imaging through the thinned skull with 1700 nm optical coherence microscopy (Conference Presentation) Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280P (9 March 2020)
Jun Zhu, Hercules Freitas, Izumi Maezawa, Lee-Way Jin, Vivek J. Srinivasan 1700 nm optical coherence microscopy enables minimally invasive, volumetric, deep tissue optical biopsy of the mouse brain in vivo (Conference Presentation) Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162910 (2021)
Jun Zhu, Hercules Rezende Freitas, Izumi Maezawa, Lee-way Jin and Vivek J. Srinivasan 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain Light: Science & Applications volume 10, Article number: 145 (2021)

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