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Designed to make an IMPACT
Engineered for excellence: A new hybrid photosensor for flow cytometry
The future of next-generation flow cytometry instruments is a topic of constant debate. Driven by the pressure to detect more distinct wavelengths, achieve greater sensitivity and higher throughput, while managing cost-effectiveness and ease of use, system design starts with a negotiation of tradeoffs –
Sensitivity or dynamic range?
Ease of use or sophisticated versatility?
High performance or cost effectiveness?
Qualitative output or quantitative, uniform predictable data?
What if Hypereon technology removes the need to compromise?
Hamamatsu is planning to formally launch Hypereon technologies in mid-2025. If you’re curious and would like insider updates, please bookmark this page, and sign up for further updates. We will be sending out more information soon via email, updating this page regularly, and scheduling exclusive meetings to share our preliminary data and product timeline.
Concept
Characteristics
Sensor Concept
What makes Hypereon special?
By utilizing two sequential stages of amplification, electron bombardment and then on-chip APD gain, Hypereon has it all: sensitivity, wide dynamic range, temperature stability, small package size and sensor-to-sensor uniformity. Leveraging decades of PMT and APD experience, specifically in flow cytometry, Hypereon simplifies high performance instrument design and, when combined with our photon number quantification (PNQ) algorithm, turns qualitative data into quantitative, comparable information.
Hy-photocathode series
Products that incorporate Hypereon technology will take advantage of the Hy-photocathode series.
The boosted quantum efficiency across a broad spectrum is the key benefit of Hy-photocathodes, and is a key factor in how Hypereon technology creates opportunities for advances in flow cytometry.
Multiplication principle
1. Photon to photoelectron conversion.
Incoming photons hit the Hy-photocatode and are converted to photoelectrons. There is no amplification in the step but the percentage of photons that are converted to photoelectrons depends on the wavelength of the light and the design of the photocathode.
2. Electron bombardment gain.
Photoelectrons from the cathode are now accelerated into the silicon. The first signal amplification occurs when the accelerated electrons hit the silicon, causing the release of additional electrons. This step has the highest gain of the two amplification steps.
3. Avalance photodiode (APD) gain.
The electrons multiplied by the first step are now further amplified by the sensor's avalanche photodiode.
- Confirmation
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