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FDSS7000EX Functional Drug Screening System

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The FDSS7000EX is our high-end model capable of handling 1536-well assays and measuring both fluorescence and luminescence, and is equipped with a variety of functions such as multiple washing. Many kinds of suspended/adherent cells' real-time kinetic reactions can be measured and analyzed. Various optional parts such as FRET, robot connections, etc. are available. In addition, the FDSS7000EX is expandable for future upgrades.

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Applications

  • Intracellular calcium ion
  • Membrane potential
  • Ion channel
  • Aequorin
  • FRET
  • Suspended cell

◇Measurement example: Intracellular calcium ion
Comparison of calcium mobilities using Aequorin, Fluo-3, and Fura-2 receptor-expressing cells.

fdss7000ex application

 

 

Hardware

Dispenser

Can be equipped with various dispenser heads

  • 96-, 384-, or 1536-tip dispenser heads are selectable. The tips are exchangeable.
  • 384- and 1536-pintool heads are also supported.
  • The main unit is equipped with an automatic tip loading feature.
  • As standard, three types of compounds can be dispensed. If you use the back plate loading line, up to four types of compounds can be dispensed.
  • The dispenser heads can be easily changed by the user.

Washing unit

Equipped with a variety of washing features

  • Up to three solvents are supported, which enables washing with no carry over.
  • Tips can be washed during measurement.
  • An ultrasound washing feature is also available.
  • Equipped with a wiping stage to dry tip ends.

Plate stacker unit

Plate stacker feature for 20 or 50 plates

  • Using the plate stacker makes it possible to perform automatic measurements even without the use of a robot.
  • You can select 20 plates or 50 plates.
  • Stacker cassette method makes it easy to set plates.
  • Can be equipped with a barcode reader.

Plate shaking features

Plate shaking provides stable response detection.

  • Measurements can be performed while applying fine vibrations to the whole plate.
  • Cells and reagents can be mixed effectively and quickly.
  • This is also effective for assays that use suspended cells.

Fluorescence/luminescence sensor, Fluorescence optics

Supports fluorescence assays and luminescence assays with a single sensor

  • This sensor has a fluorescence detection sensitivity that far exceeds that of conventional fluorescence sensors.
  • Because the excitation light can be lowered, the cost of purchasing excitation light sources can be reduced.
  • In addition to high sensitivity, the FDSS7000EX also has a high dynamic range.
  • The fluorescence changer makes FRET measurements possible.

Various assays with xenon lamp & filter combination (multiple excitation and emission)

  • Good wavelength separation by epi-illumination optics
  • Fura-2 assay with dual excitation (340 nm & 380 nm)
  • FRET (C/Y, Membrane potential) with emission filter changer
  • 2 dichroic mirror and 4 emission filter slots for various assays
  • White light xenon lamp with wattage options (150 W, 300 W, 600 W)
  • 6 filter slots for excitation
  • Uniform plate illumination

Specifications

Type number FDSS7000EX
Main unit dimensions Approx. 1500 mm (W)×1030 mm (D)×1450 mm (H)
Main unit Up to approx. 300 kg
Data analysis system dimensions 600 mm (W)×700 mm (D)×1500 mm (H)
Data analysis system weight Approx. 50 kg
Pump unit/Tank dimensions 500 mm (W)×500 mm (D)×1200 mm (H)
Pump unit/Tank weight Approx. 50 kg

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