1700 nm帯の広帯域波長光源を用いることで、高散乱な生体組織の深部の高分解能イメージングが可能です。具体的には、SD-OCM (Spectral Domain - Optical Coherence Microscopy)により、開頭手術なしの非侵襲脳神経細胞深部イメージングができるため、アルツハイマー病変のIn-vivo観察などで応用されています。
|Jun Zhu and Vivek J. Srinivasan||In vivo mouse brain imaging through the thinned skull with 1700 nm optical coherence microscopy (Conference Presentation)||Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280P (9 March 2020)|
|Jun Zhu, Hercules Freitas, Izumi Maezawa, Lee-Way Jin, Vivek J. Srinivasan||1700 nm optical coherence microscopy enables minimally invasive, volumetric, deep tissue optical biopsy of the mouse brain in vivo (Conference Presentation)||Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162910 (2021)|
|Jun Zhu, Hercules Rezende Freitas, Izumi Maezawa, Lee-way Jin and Vivek J. Srinivasan||1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain||Light: Science & Applications volume 10, Article number: 145 (2021)|
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