Product developmentIonization-assisting substrates achieving matrix-free mass spectrometryMass spectrometry is an analytical technique used to accurately analyze the types, quantities and structures of atoms and molecules within a sample. By irradiating a laser beam or electron beam on the sample, you can ionize them and measure their mass. Demands for mass spectrometry are growing in the recent years for application in a wide range of elds such as environment, food and life sciences. MALDI(*3) TOF-MS(*4), which is one method of ionization in mass spectrometry, uses a substance (matrix) to enhance the ef ciency of ionization by the laser beam, and this caused some problems: the sample pretreatment process is time-consuming because it requires mixing the matrix with the sample, and measuring was dif cult in lower molecular region because the matrix itself was ionized. Just by placing the newly developed ionization-assisting substrates(*5) on the sample, the molecules in the sample rise to the surface of substrates by capillary action in the through holes(*6), allowing ionization by irradiation of the laser beam onto molecules without using any matrix, drastically reducing the pretreatment time needed compared to the conventional MALDI TOF-MS and providing highly accurate measurements in low molecular region. Looking forward, the Company will improve the structural design to enhance the ef ciency of ionization and develop products that are compatible with various applications.X-ray line sensor cameras that can be used for a wide range of applicationsX-ray line sensor cameras are used to capture the inside of objects transported on a conveyor belt or similar apparatus, and are used widely in non-destructive testing applications for food and electronic components. Due to the diverse types of objects to be inspected, particularly in the recent years, there are demands for products that are compatible with various applications. Given these circumstances, the Company developed a new X-ray line sensor camera with a signi cantly greater range of detection, achieving lower noise and higher sensitivity as a result of fundamental review of the sensor structure. This product is capable of inspecting objects that are thin and light that use weak X-rays as well as objects that are thick and dense that require greater X-rays, and can be used for a wide range of testing applications. Other features include double scan speed compared to conventional products for reduced testing time, downsized, and equipped with waterproof and dust-proof functions suitable for all kinds of sites. We will continue to develop products that address market needs for highly precise non-destructive testing.(*3) Acronym for Matrix Assisted Laser Desorption/Ionization(*4) Acronym for Time of Flight Mass Spectrometry. By creating potential difference in the space that the ion travels to reach the detector and separating the ions by mass, it is used to measure mass based on the time taken for an ion to travel to the detector.(*5) Results of this development was achieved through joint development with the Graduate School for the Creation of New Photonics Industries.(*6) A phenomenon in which the liquid inside the thin tube moves inside the tube.MATRIXIonization-assistingsubstratesGlass slideTargetsampleIonIonLaserbeamLaserbeamLaser ionization usingionization-assistingsubstratesMALDIMolecules insample rise due tocapillary actionIn general MALDI, MATRIX is ionized together with target sample when laser irradiation. On the other hand, laser desorption ionization using ionization-assisting substrates makes it possible to ionize the target sample only.Newly developed X-ray line sensor camera9Annual Report 2018


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