CYTOQUBE™ (Light-Sheet Microplate Cytometer) Prototype equipped with Zyncscan™ technology
In drug discovery and development, there is a rapidly growing need to use more physiologically-relevant in vitro cell culture models. These include primary cells, patient-derived cells, human iPSC-derived disease-modeling cells, co-cultures of different types of cells, and 3D cultures such as spheroids and organoids. To develop and advance phenotypic assays and screenings using these physiologically-relevant cellular models, new types of instruments needed to be developed to facilitate high-throughput fluorescence imaging and measurement of heterogeneous 2D and 3D cell cultures. To meet this need, we have developed Zyncscan™ technology that performs an x-z plane scan utilizing a light-sheet for a microplate.
Zyncscan™ technology consists of a hardware component for fluorescence measurement (an x-z plane scanning with a light-sheet for a microplate) and a data handling component to extract cell fluorescence 3D signals from the background in the scanned fluorescence image, which Hamamatsu Photonics K.K. originally developed. Please see the principle and features of this wonderful technology in the movie below.
Principle of Zyncscan™ technology
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