MoxiePlex Multi-spectral imaging system

C16919-01

The MoxiePlex® Multi-spectral imaging system captures high-resolution images of entire tissue samples stained with multiple fluorescent dyes. These images play a pivotal role in evaluating and visualizing biomarker localization and expression levels, empowering researchers to perform comprehensive analysis.

 

MoxiePlex is a registered trademark of Hamamatsu Photonics K.K. (China, EU, Japan, Switzerland, UK).

Acquire high-resolution images with up to 9 channels

The MoxiePlex is designed to speed up multiplex immunofluorescence research by providing up to 9 channels across the entire tissue section.

With a 16 bit output, it delivers high-resolution imaging essential for image analysis. Additionally, the system is equipped with a state-of-the-art camera featuring high quantum efficiency across a 400 nm to 900 nm wavelength range, allowing for a broader selection of fluorescent reagents and enhanced biomarker detection.

Spectral sensitivity

Spectral sensitivity

Imaging examples

Akoya Biosciences MOTiF PD-1/PD-L1 Panel 7plex kit

Imaging example

Akoya Biosciences MOTiF PD-1/PD-L1 Panel 5plex kit

Imaging example

SignalStar™ Multiplex IHC Kit

Imaging example

Overlay image of DAPI (blue) and individual targets (white)

Overlay image of DAPI (blue) and individual targets (white)

Compatible with BF

The MoxiePlex enables seamless superimposition of brightfield and fluorescence images within the Moxie software. It captures high-resolution images of H&E-stained, immunohistochemically (IHC)-stained, and specially stained samples, providing a comprehensive view of tissue morphology for in-depth observation and analysis.

H&E

H&E

IHC

IHC

Automated sample recognition and exposure time calculation

The MoxiePlex uses proprietary fluorescence optics technology and algorithms to automate sample recognition, scan range setting, focus position setting, and exposure time calculation.  Users can choose between fully automated operation to minimize manual effort or manual adjustments for greater flexibility and control.

Conventional flow and MoxiePlex automatic flow

Features of each flow

Features of each flow

Automatically recognizes the entire tissue sample and automatically calculates exposure time to acquire fluorescent images

The MoxiePlex enhances immunofluorescence imaging by automatically detecting tissue samples that are challenging to identify in brightfield imaging. It intelligently sets scan profiles and optimizes exposure time for precise fluorescent image acquisition, ensuring a seamless workflow and high accuracy. (Patent pending)

Flow of getting acquisition of fluorescence image

Specifications

Product name MoxiePlex Multi-spectral imaging system
Product number C16919-01
Cassette loader Up to 60 slides
Compatible glass slide

75.0 mm to 76.0 mm × 25.0 mm to 26.0 mm (Thickness: 0.9 mm to 1.2 mm)

Objective lens

20× NA 0.8

Scanning resolution 20x mode 0.46 μm/pixel
40x mode 0.23 μm/pixel
Brightfield scan speed 20x mode Approx. 60 s(15 mm × 15 mm)
40x mode Approx. 70 s(15 mm × 15 mm)
Fluorescence throughput *1 20x mode Approx. 12 min.(15 mm × 15 mm, 5 channels)
40x mode Approx. 14 min.(15 mm × 15 mm, 5 channels)
Fluorescence camera In-house sCMOS camera
Z-stack feature Included
Image format OME-TIFF (16 bit, 8 bit), NDPI (8 bit)
Power supply AC 100 V to AC 240 V
Power consumption Approx.  180 VA

*1 Fluorescence throughput: The time from loading the glass slide, macro photography, prefocusing 5 points, scanning, image processing, to unloading the glass slide.

Dimensions

Dimensional outlines

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