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MoxiePlex Multi-spectral imaging system
C16919-01
The MoxiePlex Multi-spectral imaging system captures high-resolution images of entire tissue samples stained with multiple fluorescent dyes. These images support spatial proteomics workflows and accelerate translational research in drug discovery.
- Acquire high-resolution images with up to 9 channels
- Imaging examples by reagent product
- Automated sample recognition and exposure time calculation
- Unmixing technology for multiplex fluorescence analysis
- Library creation for enhanced unmixing accuracy
- Related documents
- Related videos
- Specifications
- Dimensions
Acquire high-resolution images with up to 9 channels
The MoxiePlex provides up to 9 channels of fluorescence imaging across the entire tissue section on a glass slide.
With a 16-bit output, it delivers high-resolution imaging essential for image analysis. Additionally, the system is equipped with a state-of-the-art camera featuring high quantum efficiency across a 400 nm to 900 nm wavelength range, allowing for a broader selection of fluorescent reagents and enhanced biomarker detection.
Spectral sensitivity
Imaging examples by reagent product
7-color multiplex fluorescence IHC detection kit
Six-plex overlay image of paraffin-embedded tonsil tissue sample
Vizgen “InSituPlex®” 4-plex OmniVUE™ Panels
4-plex overlay image of paraffin-embedded tonsil tissue sample
Staining principle of InSituPlex®
Cleavable Tyramide (TSA) Technology
7-plex overlay image of paraffin-embedded human tonsil sample
Cleavable Tyramide (TSA) Technology
Cleavable Fluorescent Probe (CFP) - Spatomics’ Exclusive and Original Spatial Multiplexing Technology
- Proprietary cleavable TSA fluorophores designed for iterative staining & imaging
- Compatible with standard, off-the-shelf antibodies
- Best-in-class sensitivity and fluorescent dye selection
- Efficient fluorophore cleavage without loss of protein antigeneity
- Significantly reduce costs and development cycles for multiplex protein assays
- Compatible with on market RNA ISH assays for protein-RNA co-detection
NaveniFlex™ Tissue Kit
4-plex overlay image of paraffin-embedded human colon sample
SignalStar® Multiplex IHC Kit
5-plex overlay image of paraffin-embedded human gastric cancer tissue
Overlay image of DAPI (blue) and individual targets (white)
MOTiF PD-1/PD-L1 Panel 7-plex Kit
7-plex overlay image of paraffin-embedded human tonsil sample
Compatible with BF
The MoxiePlex allows side-by-side visualization of brightfield and fluorescence images within the MoxiePlex software. It captures high-resolution images of H&E-stained, immunohistochemically (IHC)-stained, and specially stained samples, providing a comprehensive view of tissue morphology for in-depth observation and analysis.
H&E
IHC
Automated sample recognition and exposure time calculation
The MoxiePlex uses proprietary fluorescence optics technology and algorithms to automate sample recognition, scan range setting, focus position setting, and exposure time calculation. This not only reduces the manual workload required for setup, but also improves reproducibility when performing repeated measurements under the same conditions. Users can choose between fully automated operation to minimize manual effort or manual adjustments for greater flexibility and control. Furthermore, unmixing processing can be performed simultaneously with scanning, enabling efficient transition from data acquisition to analysis.
Proprietary fluorescence optical technology enabling automation
In MoxiePlex, the entire tissue sample is first imaged using low magnification and a wide field of view prior to scanning.
Based on these images, the system automatically detects the sample, adjusts exposure time, and determines optimal focus positions, enabling automation of processes that traditionally required manual adjustment. (Patent pending)
Unmixing technology for multiplex fluorescence analysis
Unmixing in multiplex fluorescence staining is an analytical method that separates overlapping fluorescence signals into their individual components.
By applying unmixing techniques, MoxiePlex enables accurate extraction of target fluorophore signals while maintaining quantitative fluorescence intensity, even in multiplex-stained samples where spectral overlap and crosstalk are prevalent.
Additionally, this approach reduces autofluorescence components with broad emission spectra, such as those originating from red blood cells, contributing to improved signal separation performance and enhanced analytical accuracy in multiplex fluorescence analysis.
When detecting Opal 780
Library creation for enhanced unmixing accuracy
MoxiePlex is equipped with a library creation function that enables the generation of libraries used for unmixing from pre-acquired images of single-stained samples.
In addition, for samples exhibiting autofluorescence, libraries including autofluorescence components can also be created, enabling more accurate unmixing analysis.
The system also allows flexible updating of libraries in response to changes in assay conditions or imaging systems, helping to reduce operational costs and processing time associated with unmixing analysis.
MoxiePlex library creation workflow
Application examples
Evaluation of a multiplex fluorescence–stained sample (7-plex)
Autofluorescence
Related documents
An interview article published on the website of the scientific journal Nature.
This article is an interview published on the website of the world‑renowned scientific journal Nature. In this discussion, three experts—Dr. Carlo Bifulco (Providence Genomics), Dr. David Rimm (Yale University), and Don Ariyakumar (HAMAMATSU CORPORATION)—share their perspectives on the clinical application of spatial proteomics technologies, which enable detailed analysis of proteins within cancer cells and their surrounding microenvironment. They also discuss the unique features of MoxiePlex and its contributions to diagnostics and therapeutic decision‑making.
Related videos
SITC 2025 - From Spatial Biology to Clinical Utility: Advancing Lung Cancer Diagnostics
The SITC 2025 session, “From Spatial Biology to Clinical Utility: Advancing Lung Cancer Diagnostics,” explores cutting-edge advancements in spatial biology technologies and their transformative potential in improving lung cancer diagnosis and treatment strategies. The discussion features insights from Dr. Carlo Bifulco, Chief Medical Officer at Providence Genomics and Director of Translational Molecular Pathology at EACRI, and Xiaoshan Wang, VP of Business Development for Spatomics, and who share perspectives from both industry and clinical research.
From 1:40｜Maximizing Diagnostic Power from Limited Lung Cancer Tissue
Carlo Bifulco, MD – Chief Medical Officer at Providence Genomics | Director of Translational Molecular Pathology at the Earle A Chiles Research Institute
From 34:43｜Breaking the Multiplex Barrier with CFP™ Cleavable Tyramide Technology
Xiaoshan Wang – Spatomics
Specifications
| Product name | MoxiePlex Multi-spectral imaging system | |
|---|---|---|
| Product number | C16919-01 | |
| Cassette loader | Up to 60 slides | |
| Compatible glass slide | 75.0 mm to 76.0 mm × 25.0 mm to 26.0 mm (Thickness: 0.9 mm to 1.2 mm) |
|
| Objective lens | 20× NA 0.8 |
|
| Scanning resolution | 20x mode | 0.46 μm/pixel |
| 40x mode | 0.23 μm/pixel | |
| Brightfield scan speed | 20x mode | Approx. 60 s（15 mm × 15 mm） |
| 40x mode | Approx. 70 s（15 mm × 15 mm） | |
| Fluorescence throughput *1 | 20x mode | Approx. 12 min.（15 mm × 15 mm, 5 channels） |
| 40x mode | Approx. 14 min.（15 mm × 15 mm, 5 channels） | |
| Fluorescence camera | In-house CMOS camera | |
| Z-stack feature | Included | |
| Image format | OME-TIFF (16 bit, 8 bit), NDPI (8 bit) | |
| Power supply | AC 100 V to AC 240 V | |
| Power consumption | Approx. 180 VA | |
*1 Fluorescence throughput: The time from loading the glass slide, macro photography, prefocusing 5 points, scanning, image processing, to unloading the glass slide.
Dimensions
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