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MoxiePlex Multi-spectral imaging system
C16919-01
The MoxiePlex® Multi-spectral imaging system captures high-resolution images of entire tissue samples stained with multiple fluorescent dyes. These images support spatial proteomics workflows and accelerate translational research in drug discovery.
MoxiePlex is a registered trademark of Hamamatsu Photonics K.K. (China, EU, Japan, Switzerland, UK).
Acquire high-resolution images with up to 9 channels
The MoxiePlex provides up to 9 channels of fluorescence imaging across the entire tissue section on a glass slide.
With a 16 bit output, it delivers high-resolution imaging essential for image analysis. Additionally, the system is equipped with a state-of-the-art camera featuring high quantum efficiency across a 400 nm to 900 nm wavelength range, allowing for a broader selection of fluorescent reagents and enhanced biomarker detection.
Spectral sensitivity
Imaging examples by reagent product
Vizgen “InSituPlex®” 4 plex OmniVUE™ Panels
Four-plex overlay image of paraffin-embedded tonsil tissue sample
Staining principle of InSituPlex®
Cleavable Tyramide (TSA) Technology
Seven-plex overlay image of paraffin-embedded human tonsil sample
Cleavable Tyramide (TSA) Technology
Cleavable Fluorescent Probe (CFP) - Spatomics’ Exclusive and Original Spatial Multiplexing Technology
- Proprietary cleavable TSA fluorophores designed for iterative staining & imaging
- Compatible with standard, off-the-shelf antibodies
- Best-in-class sensitivity and fluorescent dye selection
- Efficient fluorophore cleavage without loss of protein antigeneity
- Significantly reduce costs and development cycles for multiplex protein assays
- Compatible with on market RNA ISH assays for protein-RNA co-detection
NaveniFlex™ Tissue Kit
Four-plex overlay image of paraffin-embedded human colon sample
SignalStar® Multiplex IHC Kit
Five-plex overlay image of paraffin-embedded human gastric cancer tissue
Overlay image of DAPI (blue) and individual targets (white)
MOTiF PD-1/PD-L1 Panel 7plex Kit
Seven-plex overlay image of paraffin-embedded human tonsil sample
Compatible with BF
The MoxiePlex side-by-side visualization of brightfield and fluorescence images within the Moxie software. It captures high-resolution images of H&E-stained, immunohistochemically (IHC)-stained, and specially stained samples, providing a comprehensive view of tissue morphology for in-depth observation and analysis.
H&E
IHC
Automated sample recognition and exposure time calculation
The MoxiePlex uses proprietary fluorescence optics technology and algorithms to automate sample recognition, scan range setting, focus position setting, and exposure time calculation. This not only reduces the manual workload required for setup, but also improves reproducibility when performing repeated measurements under the same conditions. Users can choose between fully automated operation to minimize manual effort or manual adjustments for greater flexibility and control.
Features of each flow
Automatically recognizes the entire tissue sample and automatically calculates exposure time to acquire fluorescent images
The MoxiePlex enhances immunofluorescence imaging by automatically detecting tissue samples that are challenging to identify in brightfield imaging. It intelligently sets scan profiles and optimizes exposure time for precise fluorescent image acquisition, ensuring a seamless workflow and high accuracy. (Patent pending)
Related documents
An interview article published on the website of the scientific journal Nature.
This article is an interview published on the website of the world‑renowned scientific journal Nature. In this discussion, three experts—Dr. Carlo Bifulco (Providence Genomics), Dr. David Rimm (Yale University), and Don Ariyakumar (HAMAMATSU CORPORATION)—share their perspectives on the clinical application of spatial proteomics technologies, which enable detailed analysis of proteins within cancer cells and their surrounding microenvironment. They also discuss the unique features of MoxiePlex and its contributions to diagnostics and therapeutic decision‑making.
Related videos
SITC 2025 - From Spatial Biology to Clinical Utility: Advancing Lung Cancer Diagnostics
The SITC 2025 session, “From Spatial Biology to Clinical Utility: Advancing Lung Cancer Diagnostics,” explores cutting-edge advancements in spatial biology technologies and their transformative potential in improving lung cancer diagnosis and treatment strategies. The discussion features insights from Dr. Carlo Bifulco, Chief Medical Officer at Providence Genomics and Director of Translational Molecular Pathology at EACRI, and Xiaoshan Wang, VP of Business Development for Spatomics, and who share perspectives from both industry and clinical research.
From 1:40｜Maximizing Diagnostic Power from Limited Lung Cancer Tissue
Carlo Bifulco, MD – Chief Medical Officer at Providence Genomics | Director of Translational Molecular Pathology at the Earle A Chiles Research Institute
From 34:43｜Breaking the Multiplex Barrier with CFP™ Cleavable Tyramide Technology
Xiaoshan Wang – Spatomics
Specifications
| Product name | MoxiePlex Multi-spectral imaging system | |
|---|---|---|
| Product number | C16919-01 | |
| Cassette loader | Up to 60 slides | |
| Compatible glass slide | 75.0 mm to 76.0 mm × 25.0 mm to 26.0 mm (Thickness: 0.9 mm to 1.2 mm) |
|
| Objective lens | 20× NA 0.8 |
|
| Scanning resolution | 20x mode | 0.46 μm/pixel |
| 40x mode | 0.23 μm/pixel | |
| Brightfield scan speed | 20x mode | Approx. 60 s（15 mm × 15 mm） |
| 40x mode | Approx. 70 s（15 mm × 15 mm） | |
| Fluorescence throughput *1 | 20x mode | Approx. 12 min.（15 mm × 15 mm, 5 channels） |
| 40x mode | Approx. 14 min.（15 mm × 15 mm, 5 channels） | |
| Fluorescence camera | In-house CMOS camera | |
| Z-stack feature | Included | |
| Image format | OME-TIFF (16 bit, 8 bit), NDPI (8 bit) | |
| Power supply | AC 100 V to AC 240 V | |
| Power consumption | Approx. 180 VA | |
*1 Fluorescence throughput: The time from loading the glass slide, macro photography, prefocusing 5 points, scanning, image processing, to unloading the glass slide.
Dimensions
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