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Activation of G(q) protein-coupled receptors can be monitored by measuring the increase in intracellular calcium with fluorescent dyes. Recent advances in fluorescent kinetic plate readers and liquid-handling technology have made it possible to follow these transient changes in intracellular calcium in a 1536-well plate format for high-throughput screening (HTS). Here, we have applied the latest generation of fluorescence kinetic plate readers to multiplex the agonist and antagonist screens of a G protein-coupled receptor (GPCR). This multiplexed assay format provides an efficient and cost-effective method for HTS of G(q)-coupled GPCR targets.

Assay Drug Dev Technol. 2010 Jun;8(3):367-79. doi: 10.1089/adt.2009.0245.

Related scientific material

Authors Title Source
Ke Liu, Noel Southall, Steve A. Titus, James Inglese, Robert L. Eskay, Paul Shinn, Christopher P. Austin, Markus A. Heilig and Wei Zheng A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists Assay Drug Dev Technol. 2010 Jun;8(3):367-79


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  • Please note that information in posters and presentations used in past conferences and symposiums may now be slightly different. As Hamamatsu are solely an equipment manufacturer, we are not responsible for measurement samples or data presented in these materials.

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