High-throughput screening (HTS) and high-content screening (HCS) are related analytical techniques of studying biological systems in parallel, common in cell biology and pharmaceutical drug discovery. For example, to study the effect of a drug on a specific bacterium, samples of the bacterium are placed in the wells of a biological assay. A drug is then introduced, perhaps in different amounts, and all the wells of the assay are screened simultaneously with one or more analytical techniques such as fluorescence microscopy, Raman scattering, confocal microscopy, and more. The tests are fully automated, allowing thousands to millions of experiments testing the effectiveness of a multitude of compounds in treating a disease, and to ascertain efficacy of promising drugs.
HTS/HCS systems involve many complex instruments working together: a fluid handler for changing assay reagents, a robot to move 96- or 384-well plates in and out of the work station, and an imaging device to record data. Once the data is recorded, complex software analysis is performed to identify compounds of interest for further evaluation. These systems are the backbone of modern drug discovery, efficacy testing, and validation.
A high-sensitivity 2D sensor in the camera allows for simultaneous measurement and analysis of fluorescence or luminescence in all wells.
The low noise and high resolution properties of the sCMOS cameras satisfy the sensitivity and quantitative requirements for high content screening in a short exposure time.
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