Case study | qCMOS^® cameras

Quantum Technology

Imaging single atom array by ORCA^®-Quest for Neutral Atom Quantum Computing【Osaka university】

To reach a large-scale general-purpose quantum computer, several approaches are being proposed (e.g., superconducting qubit, trapped ion qubit), but it has yet to be decided which one is the winner. A scientific camera is commonly used in a quantum computer with neutral atom, one of the most promising qubits. We interviewed Professor Takashi Yamamoto and Associate Professor Toshiki Kobayashi of Osaka University, who are using ORCA-Quest for neutral atom quantum computing.

Mid-circuit imaging by ORCA^®-Quest qCMOS^® camera in an error-corrected neutral-atom quantum computer【Harvard university, QuEra Computing, MIT, and NIST/UMD】

ORCA-Quest qCMOS camera from Hamamatsu was chosen as a camera for mid-circuit imaging in an error-corrected neutral-atom quantum computer. The experiments was led by Harvard university in close collaboration with QuEra Computing, MIT, and NIST/UMD.

Life science

Single-molecule fluorescence observation of cells using ORCA^®-Quest【Gifu university】

The Cell Biophysics Laboratory of the Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System, Gifu University, is researching to elucidate the mechanisms of molecules present within cells and on cell membranes. In 2022, this laboratory introduced the ORCA-Quest as a camera for single-molecule fluorescence observation. We interviewed Professor Kenichi Suzuki and Researcher Koichiro Hirosawa of this laboratory, as well as Rinshi Kasai, who was a member of the laboratory until May 2023 and is currently Unit Head of the Advanced Bioimaging Research Division at the National Cancer Center Research Institute, about the reasons for introducing ORCA-Quest, their experience using it, and the outlook for future research.

Pushing the limits of bioluminescence microscopy【Institut de Ciencies Fotòniques】

Bioluminescent microscopy’s unique advantages are pushing researchers to challenge it against conventional fluorescent methods. When detecting and imaging live cells and animals, the use of bioluminescence reporters has shown to be a promising method, especially in neuroscience research. Dr. Michael Krieg, from ICFO, Institut de Ciencies Fotòniques, Castelldefels, Spain, and his collaborators demonstrate volumetric imaging of fast cellular dynamics by exposing the advantages and pushing the limits of bioluminescence microscopy on Caenorhabditis elegans and other biological model organisms.

In vivo quantification of neuronal activity in zebrafish【Max Planck Institute】

Presently doing research at the Max Planck Institute for Biological Cybernetics in Germany, Dr. Drew Robson methodically develops the different approaches to observe the zebrafish larvae brain function during its natural behavior with a quantitative photon number-resolving camera.

Comparison on single molecule microscopy imaging with EM-CCD and qCMOS^® camera ORCA^®-Quest 【Institute of Genetics and Developmental Biology, Chinese Academy of Sciences】

In order to achieve the best performance of single molecule imaging, Dr. Jiachao Xu, from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, built a TIRF microscope and has been continuously improving it in past several years. Recently, Dr. Xu compared the performance of two kinds of cameras, EM-CCD and qCMOS, in his experiment of single molecule fluorescence imaging of angiotensin II type 1 receptor (AT1R) in living cells.

Astronomy

Aurora observation with ORCA^®-Quest【University of Electro-Communications】

The Hosokawa Laboratory from the Department of Communication Engineering and Informatics at The University of Electro-Communications uses a high-sensitivity camera to observe auroras.Observation of auroras requires a high frame rate to observe morphology and dynamics, high sensitivity to detect dark auroras, low noise for smooth analysis of acquired images, and large sensor size for wide-field imaging. The ORCA-Quest qCMOS^® camera solves these problems.

High energy physics Synchrotron radiation

Development of hadron imaging technology for application in hadron radiotherapy【National Institute of Advanced Industrial Science and Technology (AIST)】

The Advanced Beam Measurement Group at the Research Institute for Measurement and Analytical Instrumentation, part of the National Metrology Institute of Japan (NMIJ) under the National Institute of Advanced Industrial Science and Technology (AIST), is working on developing alpha-ray imaging technology for advanced heavy ion radiotherapy. Our ORCA^®-Quest qCMOS^® camera is utilized as a detector in this research.

Development of X-ray micro-imaging system at synchrotron radiation facility【JASRI】

Japan Synchrotron Radiation Research Institute (JASRI) supports operating, maintaining, and utilizing the SPring-8 large synchrotron radiation facility. They also support using the SACLA and the NanoTerasu. Among them, the Microscopic and Dynamic Imaging Team, Scattering and Imaging Division, is responsible for developing X-ray imaging systems using synchrotron radiation and supporting researchers who would like to acquire X-ray micro-images. The ORCA^®-Quest qCMOS^® camera is used as the detector for the X-ray micro-imaging system.

Spectroscopy

qCMOS^® camera evaluation in Tip-enhanced Raman scattering【Shanghai UPU Optoelectronic Technology Co.】

qCMOS camera has excellent weak signal detection ability because of its excellent characteristics such as very low dark noise. In this experiment, a qCMOS camera and a grating spectrometer were combined, and a new software was developed to control both at the same time for detecting Tip-enhanced Raman scattering (TERS). For this purpose, the detection capability of qCMOS camera on Raman or weak signal Raman is tested, and more application possibilities are explored.

Photon number resolving capability of qCMOS^® camera for Raman spectroscopy and imaging【Poster】

In Raman imaging, shortening the measurement time is a very important factor. To achieve this, it is necessary to detect Raman signals in a short period of time, which requires high sensitivity and low noise of the camera, as well as multiple pixels and high speed. We measured the SNR and spectral dynamic range of our photon number resolving camera (qCMOS camera) and compared it with the EM-CCD camera and showed the superiority of the qCMOS camera.

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Synchrotron radiation analysis "Ryugu" camera application case-study

Asteroid Ryugu, is thought to still contain water and organic compounds from 4.6 billion years ago when our solar system likely formed. We interviewed Mr. Uesugi of the Japan Synchrotron Radiation Research Institute (JASRI), who was in charge of analyzing the Ryugu samples, about the methods and results of the analysis, as well as future prospects.

This case study includes the interview with Mr. Uesugi and features our lineup of cameras suitable for synchrotron radiation imaging.

Astronomy camera application case-study

Astronomy is a field where various research is being conducted to discover and explore unknown celestial bodies and astronomical phenomena. This brochure introduces examples of such applications and our cameras suitable for each application.

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Case study | qCMOS® cameras

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