Case study | qCMOS^® cameras

Quantum Technology

Imaging single atom array by ORCA^®-Quest for Neutral Atom Quantum Computing【Osaka university】

To reach a large-scale general-purpose quantum computer, several approaches are being proposed (e.g., superconducting qubit, trapped ion qubit), but it has yet to be decided which one is the winner. A scientific camera is commonly used in a quantum computer with neutral atom, one of the most promising qubits. We interviewed Professor Takashi Yamamoto and Assistant Professor Toshiki Kobayashi of Osaka University, who are using ORCA-Quest for neutral atom quantum computing.

Mid-circuit imaging by ORCA^®-Quest qCMOS^® camera in an error-corrected neutral-atom quantum computer【Harvard university, QuEra Computing, MIT, and NIST/UMD】

ORCA-Quest qCMOS camera from Hamamatsu was chosen as a camera for mid-circuit imaging in an error-corrected neutral-atom quantum computer. The experiments was led by Harvard university in close collaboration with QuEra Computing, MIT, and NIST/UMD.

⁴⁰Ca+ imaging by ORCA^®-Quest for optical clock application【Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences】

In previous studies, EM-CCD was mainly used for imaging, mainly because EM-CCD has imaging sensitivity at the single-photon level. With the advent of qCMOS, it attracts the attention of many researchers in optical clock field. We conducted comparative experiments in the Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences.

Life science

Single-molecule fluorescence observation of cells using ORCA^®-Quest【Gifu university】

The Cell Biophysics Laboratory of the Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System, Gifu University, is researching to elucidate the mechanisms of molecules present within cells and on cell membranes. In 2022, this laboratory introduced the ORCA-Quest as a camera for single-molecule fluorescence observation. We interviewed Professor Kenichi Suzuki and Researcher Koichiro Hirosawa of this laboratory, as well as Rinshi Kasai, who was a member of the laboratory until May 2023 and is currently Unit Head of the Advanced Bioimaging Research Division at the National Cancer Center Research Institute, about the reasons for introducing ORCA-Quest, their experience using it, and the outlook for future research.

Pushing the limits of bioluminescence microscopy【Institut de Ciencies Fotòniques】

Bioluminescent microscopy’s unique advantages are pushing researchers to challenge it against conventional fluorescent methods. When detecting and imaging live cells and animals, the use of bioluminescence reporters has shown to be a promising method, especially in neuroscience research. Dr. Michael Krieg, from ICFO, Institut de Ciencies Fotòniques, Castelldefels, Spain, and his collaborators demonstrate volumetric imaging of fast cellular dynamics by exposing the advantages and pushing the limits of bioluminescence microscopy on Caenorhabditis elegans and other biological model organisms.

In vivo quantification of neuronal activity in zebrafish【Max Planck Institute】

Presently doing research at the Max Planck Institute for Biological Cybernetics in Germany, Dr. Drew Robson methodically develops the different approaches to observe the zebrafish larvae brain function during its natural behavior with a quantitative photon number-resolving camera.

Comparison on single molecule microscopy imaging with EM-CCD and qCMOS^® camera ORCA^®-Quest 【Institute of Genetics and Developmental Biology, Chinese Academy of Sciences】

In order to achieve the best performance of single molecule imaging, Dr. Jiachao Xu, from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, built a TIRF microscope and has been continuously improving it in past several years. Recently, Dr. Xu compared the performance of two kinds of cameras, EM-CCD and qCMOS, in his experiment of single molecule fluorescence imaging of angiotensin II type 1 receptor (AT1R) in living cells.

Spectroscopy

qCMOS^® camera evaluation in Tip-enhanced Raman scattering【Shanghai UPU Optoelectronic Technology Co.】

qCMOS camera has excellent weak signal detection ability because of its excellent characteristics such as very low dark noise. In this experiment, a qCMOS camera and a grating spectrometer were combined, and a new software was developed to control both at the same time for detecting Tip-enhanced Raman scattering (TERS). For this purpose, the detection capability of qCMOS camera on Raman or weak signal Raman is tested, and more application possibilities are explored.

Photon number resolving capability of qCMOS^® camera for Raman spectroscopy and imaging【Poster】

In Raman imaging, shortening the measurement time is a very important factor. To achieve this, it is necessary to detect Raman signals in a short period of time, which requires high sensitivity and low noise of the camera, as well as multiple pixels and high speed. We measured the SNR and spectral dynamic range of our photon number resolving camera (qCMOS camera) and compared it with the EM-CCD camera and showed the superiority of the qCMOS camera.

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Case study | qCMOS® cameras

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Case study | qCMOS^® cameras