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Case study | MEMS confocal unit
The Nano-Integration Devices and Systems Laboratory at the Research Institute of Electrical Communication (RIEC), Tohoku University, specializes in brain-inspired non-von Neumann computing and the foundational technologies for related hardware research. Within this laboratory, Associate Professor Hideaki Yamamoto's research group, the Nano-Integration Neurocomputing Systems Group, combines semiconductor microfabrication, nerve cell culture, and mathematical modeling to develop new in vitro systems for bottom-up analysis of brain functions. In these in vitro systems, cultured neurons occasionally aggregate to form a 3D structure. The group introduced the MAICO® MEMS confocal unit for 3D imaging of these aggregated neurons.
The Laboratory for Evolutionary Cell Biology of Skin, Cosmetics Course, School of Bioscience and Biotechnology, Tokyo University of Technology, is researching epidermal barrier formation mechanisms. To elucidate the mechanisms of epidermal barrier formation, it is necessary to image the epidermis in three dimensions. For this purpose, they have introduced our MAICO® MEMS confocal Unit.
We interviewed Professor. Takeshi Matsui from the same laboratory about the background of introducing the MAICO MEMS confocal unit, his impressions of its use, and the prospects for future research.
MAICO enables imaging with reduced bleed-through between wavelengths, which is an issue in multi-wavelength simultaneous observation. We will introduce how we have achieved a reduction of bleed-through.
Explanation of the principles of a confocal microscope, which enables you to acquire an image that is less blurry, higher contrast, and higher resolution.
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