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浜松ホトニクスと順天堂大学が新たな創薬スクリーニング手法確立のための共同研究契約を締結
- 浜松ホトニクス株式会社 営業推進本部 画像計測機器営業推進部
がん研究、再生医療分野において、3次元培養技術の実用化を目指し、2025年7月 から共同研究を開始
浜松ホトニクス株式会社（本社：静岡県浜松市、東証：6965）と順天堂大学大学院医学研究科（東京都文京区、洲﨑悦生教授）は、3次元培養サンプルを用いた新たな創薬スクリーニング手法の確立を目的とした共同研究契約を締結しました。2025年7月より共同研究を開始しています。
共同開発を行う背景
がん研究や再生医療分野における新薬開発では、化合物の反応を評価するために、スフェロイドやオルガノイドなどの3次元培養サンプルが広く用いられています。しかし、これらのサンプルを用いた測定には、効率性や精度の面で実用化に向けた課題が残されています。こうした課題の解決に向けて、当社のライトシートマイクロプレートサイトメータ「CYTOQUBE®」と、洲﨑教授らが開発した組織を透明化する試薬を活用し、新たな創薬スクリーニング手法の確立を目指すこととなりました。
共同研究により期待される効果
CYTOQUBEは蛍光染色した2 次元および3 次元の細胞サンプルを蛍光イメージング・解析するライトシートマイクロプレートサイトメータです。CYTOQUBEと、組織を透明化することでサンプルの深部の観察を可能にする試薬、そして洲﨑教授のもとで培われた高度な3次元解析技術を組み合わせることで、定量性と再現性に優れた評価法の確立が期待されます。
本研究を通じて、新たなスクリーニングプロトコルの構築や評価指標の創出をはかり、3次元培養技術の実用化を推進してまいります。
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