ORCA-Fusion デジタルCMOSカメラ
微弱光領域(フォトン数が少ない領域)の観察においては、画像のS/N のさらなる改善が最大の課題となっています。QEの向上は大切なアプローチでは有りますが、それ以外にS/Nを改善する方法はないのでしょうか?
浜松ホトニクスでは読み出しノイズの低減に着目し、微弱光領域においても高いS/N が得られるセンサを弊社独自に開発しました。科学計測用カメラのフロントランナーとして、ユニークな視点で新時代を切り開きます。低ノイズ・高画質 第3 世代Gen Ⅲ sCMOS カメラORCA-Fusion の誕生です。
ライトシート読み出しモードは、ライトシート顕微鏡画像のS/Nを改善するsCMOSカメラの読み出し方法です。
ライトシート読み出しモードの原理や特長について詳しくはこちらをご覧ください。
著者 | タイトル | 書名 |
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Piatkevich, K.D., Bensussen, S., Tseng, Ha. et al. | Population imaging of neural activity in awake behaving mice | Nature 574, 413–417 (2019). |
Silvia Benito-Kwiecinski, Stefano L. Giandomenico, Magdalena Sutcliffe, Erlend S. Riis, Paula Freire-Pritchett, Iva Kelava, Stephanie Wunderlich, Ulrich Martin, Gregory A. Wray, Kate McDole, Madeline A. Lancaster | An early cell shape transition drives evolutionary expansion of the human forebrain | Cell, Volume 184, Issue 8, 2021, Pages 2084-2102.e19, |
Madhav Mantri, Gaetano J. Scuderi, Roozbeh Abedini-Nassab, Michael F. Z. Wang, David McKellar, Hao Shi, Benjamin Grodner, Jonathan T. Butcher & Iwijn De Vlaminck | Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis | Nat Commun 12, 1771 (2021). |
Kiryl D. Piatkevich, Seth Bensussen, Hua-an Tseng, Sanaya N. Shroff, Violeta Gisselle Lopez-Huerta, Demian Park, Erica E. Jung, Or A. Shemesh, Christoph Straub, Howard J. Gritton, Michael F. Romano, Emma Costa, Bernardo L. Sabatini, Zhanyan Fu, Edward S. Boyden & Xue Han | Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy | Nat Biotechnol 39, 609–618 (2021). |
Xinyu Wang, Chong Liu, Siwei Zhang, Huiwen Yan, Liwen Zhang, Amin Jiang, Yong Liu, Yun Feng, Di Li, Yuting Guo, Xinyao Hu, Yajing Lin, Pengcheng Bu, Dong Li, | N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles | Developmental Cell, Volume 56, Issue 5, 2021, Pages 702-715.e8, |
Emily C. Wheeler, Anthony Q. Vu, Jaclyn M. Einstein, Matthew DiSalvo, Noorsher Ahmed, Eric L. Van Nostrand, Alexander A. Shishkin, Wenhao Jin, Nancy L. Allbritton & Gene W. Yeo | Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors | Nature Methods volume 17, pages636–642 (2020) |
Scott M. Emrich, Ryan E. Yoast, Ping Xin, Vikas Arige, Larry E. Wagner, Nadine Hempel, Donald L. Gill, James Sneyd, David I. Yule, Mohamed Trebak, | Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling | Cell Reports, Volume 34, Issue 9, 2021, 108760, |
Tomomi Suzuki, Tetsuo Mioka, Kazuma Tanaka & Akira Nagatani | An optogenetic system to control membrane phospholipid asymmetry through flippase activation in budding yeast | Sci Rep 10, 12474 (2020). |
Nicholas S. Groves,Merissa M. Bruns and Schuyler B. van Engelenburg | A Quantitative Live-Cell Superresolution Imaging Framework for Measuring the Mobility of Single Molecules at Sites of Virus Assembly | Pathogens 2020, 9(11), 972 |
Pierre Stömmer, Henrik Kiefer, Enzo Kopperger, Maximilian N. Honemann, Massimo Kube, Friedrich C. Simmel, Roland R. Netz & Hendrik Dietz | A synthetic tubular molecular transport system | Nat Commun 12, 4393 (2021). |
Hugh Sparks, Lucas Dent, Chris Bakal, Axel Behrens, Guillaume Salbreux, and Chris Dunsby | Dual-view oblique plane microscopy (dOPM) | Biomed. Opt. Express 11, 7204-7220 (2020) |
Philipp Zelger, Lisa Bodner, Martin Offterdinger, Lukas Velas, Gerhard J. Schütz, and Alexander Jesacher | Three-dimensional single molecule localization close to the coverslip: a comparison of methods exploiting supercritical angle fluorescence | Biomed. Opt. Express 12, 802-822 (2021) |
型名 | C14440-20UP |
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撮像素子 | 科学計測用CMOSイメージセンサ |
有効画素数 | 2304 (H) × 2304 (V) |
画素サイズ | 6.5 μm×6.5 μm |
有効素子サイズ | 14.976 mm (H) × 14.976 mm (V) |
飽和電荷量 | 15 000 electrons(typ.) |
読み出し速度 | Fast scan:89.1 フレーム/秒(CoaxPress動作)、31.6 フレーム/(USB 3.0 動作、16 bit) (2304×2304) Fast scan:100 フレーム/秒(CoaxPress動作 / 2304×2048) Standard scan:23.2 フレーム/秒(CoaxPress動作)、23.2 フレーム/秒(USB 3.0 動作) (2304×2304) Ultra quiet scan:5.42 フレーム/秒(CoaxPress動作)、5.42 フレーム/秒(USB 3.0 動作) (2304×2304) |
読み出しノイズ | Fast scan:1.4 electrons rms Standard scan:1.0 electrons rms Ultra quiet scan:0.7 electrons rms |
露光時間 | Fast scan:17 μs~10 s (4.87 μs step) Standard scan:65 μs~10 s (18.65 μs step) Ultra quiet scan:280 μs~10 s (80.00 μs step) |
冷却方式 | ペルチェ冷却 |
冷却温度 | 強制空冷(周囲温度+25℃):-5 ℃ 水冷(水温+25 ℃):-5 ℃ 水冷(最大冷却)(水温+15 ℃ 周囲環境温度+20 ℃ の時):-15 ℃ |
暗電流 | 0.5 electrons/pixel/s(センサ温度:-5 ℃、周囲温度:+25 ℃)(typ.) 0.5 electrons/pixel/s(センサ温度:-5 ℃、水温:+25 ℃)(typ.) 0.2 electrons/pixel/s(センサ温度:-15 ℃、水温:+20 ℃、周囲環境温度:+20 ℃)(typ.) |
ダイナミックレンジ | 21 400 : 1 *1(typ.) |
外部トリガモード | ノーマルエリアモード時:エッジトリガ/グローバルリセットエッジトリガ/レベルトリガ/ グローバルリセットレベルトリガ/読み出し同期トリガ/スタートトリガ ライトシート読み出しモード時:エッジトリガ/スタートトリガ |
入力コネクタ | SMA |
トリガ遅延機能 | 0μs ~ 10 s(1 μs ステップ) |
トリガ出力 | グローバル露光タイミング出力/トリガレディ出力/プログラマブルタイミング出力/ High固定/Low固定 |
出力コネクタ | SMA |
画像改善機能 | 欠陥画素補正(ON-OFF可能、白点補正3段階選択可) |
インターフェース | CoaXPress (Dual CXP-6)/USB 3.0 *2 |
A/Dコンバータ | 16 bit、12 bit、8 bit |
レンズマウント | Cマウント |
電源 | AC 100 V ~ AC 240 V 50 Hz/60 Hz |
消費電力 | 約 150 VA *3 |
動作周囲温度 | 0 ℃ ~ + 40 ℃ |
保存周囲温度 | -10 ℃ ~ + 50 ℃ |
動作周囲湿度 | 30 % ~ 80 %(結露しないこと) |
保存周囲湿度 | 90 %以下(結露しないこと) |
*1 飽和電荷量とUltra quiet scan時の読み出しノイズから算出
*2 USB 3.1 Gen 1と同等
*3 AC240 V 入力時の値。AC100 V 入力時は約70 VA
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